The Dose–Response Effect of Lycopene on Cerebral Vessel and Neuron Impairment Induced by Hyperlipidemia

Objective:There appears to be no dose-response effect for pregabalin at doses of 300-600 mg, and a modest dose-response effect in the range of 150-300 mg. The goal of the current investigation was to determine the effect of the starting dose on the speed of onset of anxiolytic efficacy.Methods:Data were analyzed from 7 trials of outpatients with DSM-IV GAD and a HAM-A total score ≥18. Starting doses of pregabalin ranged from 100 mg (N=301) or 150 mg (N=104), to 200 mg (N=167) and 300 mg (N=388). Assessment of early improvement included the HAM-A total score and CGI-Severity and Improvement scores.Results:The mean Week 1 HAM-A change score was similar for a starting dose of 200 mg/d with no titration (-8.24) when compared to patients who started on 200 mg/d and then titrated up to 400 mg/d on Day 4 (-8.64). The mean Week 1 HAM-A change score was somewhat higher for patients started on 300 mg/d, and then titrated to 450 mg/d on Day 4/5 (-8.84) when compared to patients started on a lower (100/150 mg/d) dose and titrated on Day 5 to 400/450 mg/d (-7.32). Starting on a dose of 300 mg/d with no titration resulted in an intermediate Week 1 change score (-7.87). The interaction of starting dose and titration schedule with baseline anxiety severity will be summarized in detail.Conclusion:The initial dose of pregabalin appears to have only a weak effect on the speed of onset of anxiolytic improvement.

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U.S. lung cancer death rates begin to rise proportionately more rapidly for females than for males: A dose-response effect?

Journal of Chronic Diseases ◽

10.1016/0021-9681(72)90211-1 ◽

1972 ◽

Vol 25 (8) ◽

pp. 473-479 ◽

Cited By ~ 27

Author(s):

Fred Burbank

Keyword(s):

Lung Cancer ◽

Dose Response ◽

Cancer Death ◽

Lung Cancer Death ◽

Death Rates ◽

Response Effect ◽

Dose Response Effect

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A single dose-response effect of aflatoxin B1 on rapid liver cancer induction in two strains of rats

International Journal of Cancer ◽

10.1002/ijc.2910460419 ◽

1990 ◽

Vol 46 (4) ◽

pp. 664-668 ◽

Cited By ~ 14

Author(s):

Subhkij Angsubhakorn ◽

Panisa Get-Ngern ◽

Makoto Miyamoto ◽

Natth Bhamarapravati

Keyword(s):

Single Dose ◽

Liver Cancer ◽

Dose Response ◽

Aflatoxin B1 ◽

Response Effect ◽

Cancer Induction ◽

Dose Response Effect

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Cigarette Smoking Is Associated With a Dose-Response Effect in Clopidogrel-Treated Patients With Diabetes Mellitus and Coronary Artery Disease

JACC Cardiovascular Interventions ◽

10.1016/j.jcin.2011.09.027 ◽

2012 ◽

Vol 5 (3) ◽

pp. 293-300 ◽

Cited By ~ 40

Author(s):

Masafumi Ueno ◽

José Luis Ferreiro ◽

Bhaloo Desai ◽

Salvatore D. Tomasello ◽

Antonio Tello-Montoliu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cigarette Smoking ◽

Dose Response ◽

Response Effect ◽

Patients With Diabetes ◽

Artery Disease ◽

Dose Response Effect

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Dose-Response Effect of Adjuvant Chemotherapy in Breast Cancer

New England Journal of Medicine ◽

10.1056/nejm198101013040103 ◽

1981 ◽

Vol 304 (1) ◽

pp. 10-15 ◽

Cited By ~ 526

Author(s):

Gianni Bonadonna ◽

Pinuccia Valagussa

Keyword(s):

Breast Cancer ◽

Adjuvant Chemotherapy ◽

Dose Response ◽

Response Effect ◽

Dose Response Effect

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Smoking uptake in UK children: analysis of the UK Millennium Cohort Study

Thorax ◽

10.1136/thoraxjnl-2018-212254 ◽

2018 ◽

Vol 74 (6) ◽

pp. 607-610 ◽

Cited By ~ 8

Author(s):

Anthony A Laverty ◽

Filippos T Filippidis ◽

David Taylor-Robinson ◽

Christopher Millett ◽

Andrew Bush ◽

...

Keyword(s):

Cohort Study ◽

Dose Response ◽

Peer Group ◽

Millennium Cohort Study ◽

Response Effect ◽

Regional Estimates ◽

Smoking Uptake ◽

Uk Millennium Cohort Study ◽

Dose Response Effect ◽

The Uk

We used data from 11 577 children in the UK Millennium Cohort Study, collected at approximately 14 years of age (early teens), to assess characteristics associated with smoking, and generated regional estimates of numbers of smokers. 13.8% of UK early teens studied had ever smoked; 1.9% were current smokers. This corresponds to 2 28 136 and 39 653 (13–14 year olds) in the UK, respectively. Ever smoking risk increased if caregivers (26.0% vs 10.9%) or friends smoked (35.1% vs 4.0%), with a dose–response effect for friends’ smoking. Caregiver and peer-group smoking remain important drivers of child smoking uptake and thus important targets for intervention.

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