Mutual relationships between head injury and conduct problems in children aged 9 months to 14 years in the UK Millennium Cohort Study

Background: Research suggests a link between acquired head injury and signs of conduct disorder, with a majority of findings based on retrospective reports and comparison samples. The relationship between head injuries and conduct problems and how they may influence one another during development is currently unclear. This study aimed to investigate direct and indirect associations between head injury and conduct problems through to early adolescence. Methods: Data from the UK Millennium Cohort Study was used to investigate the relationship between conduct problems as assessed by the Strengths and Difficulties Questionnaire and parent reported head injury over time, at ages 9 months, 3, 5, 7, 11 and 14 years, using a cross-lagged path analysis. This is data from 18,552 children, participating in a UK cohort study that is representative of the UK population. We included 7,041 (3,308 male) children, who had full information about head injuries and conduct problems at age 14. Results: We found a mutual association between childhood head injuries and conduct problems but with distinct timings: Head injury between 5-7 years predicted greater chance of conduct problems at age 11 and 14 years, while greater conduct problems at 5 years predicted a significantly greater chance of a head injury at age 7-11 years. Conclusions: These findings have important implications for the timing of preventive and ameliorative interventions. Prior to school entry, interventions aiming to reduce conduct problems would appear most effective at reducing likelihood of head injuries in future years. However, equivalent interventions targeting head injuries would be better timed either as children are entering formal primary education, or soon after they have entered.

Disadvantage in early-life and persistent asthma in adolescents: a UK cohort study

ObjectiveTo determine how early-life risk factors explain socioeconomic inequalities in persistent asthma in adolescence.MethodsWe did a causal mediation analysis using data from 7487 children and young people in the UK Millennium Cohort Study. Persistent asthma was defined as having a diagnosis reported at any two or more time points at 7, 11 or 14 years. The main exposure was maternal education, a measure of early-life socioeconomic circumstances (SECs), used to calculate the relative index of inequality. We assessed how blocks of perinatal (maternal health behaviours, infant characteristics and duration of breastfeeding, measured at 9 months) and environmental risk factors (family housing conditions; potential exposure to infections through childcare type and sibling number, and neighbourhood characteristics, measured at 3 years) mediated the total effect of childhood SECs on persistent asthma risk, calculating the proportion mediated and natural indirect effect (NIE) via blocks of mediators.ResultsAt age 14 the overall prevalence of persistent asthma was 15%. Children of mothers with lower educational qualifications were more likely to have persistent asthma, with a clear social gradient (degree plus: 12.8% vs no qualifications: 20.3%). The NIE gives the effect of SECs acting only via the mediators and shows a 31% increased odds of persistent asthma when SECs are fixed at the highest level, and mediators at the level which would naturally occur at the lowest SECs versus highest SECs (NIE OR 1.31, 95% CI 1.04 to 1.65). Overall, 58.9% (95% CI 52.9 to 63.7) of the total effect (OR 1.70, 95% CI 1.20 to 2.40) of SECs on risk of persistent asthma in adolescence was mediated by perinatal and environmental characteristics.ConclusionsPerinatal characteristics and the home environment in early life are more important in explaining socioeconomic inequalities in persistent asthma in British adolescents than more distal environmental exposures outside the home.

Neighborhood and Child Development at Age Five: A UK–US Comparison

Early childhood is a critical period in the life course, setting the foundation for future life. Early life contexts—neighborhoods and families—influence developmental outcomes, especially when children are exposed to economic and social disadvantage. Residential mobility, frequent among families with pre-school children, may reduce or increase exposure to adverse surroundings. We examine children’s cognitive and behavioral outcomes at age five, in relation to neighborhood composition, family circumstances and residential moves, using two longitudinal micro datasets: an urban subsample of the UK Millennium Cohort Study (N up to 7967), and the Fragile Families and Child Wellbeing Study in the US (N up to 1820). Each is linked to an index of neighborhood advantage, created to make UK/US comparisons, based on census and administrative information. A series of estimates indicate a strong association, in both countries, between cognitive scores and neighborhood advantage, attenuated but not eliminated by family circumstances. Children’s behavior problems, on the other hand, show less association with neighborhood advantage. There are minor and mixed differences by residential mobility particularly when neighborhood disadvantage changes. Notwithstanding the primacy of the family in predicting preschool development, the findings support the notion of neighborhood as potentially advantageous at least in relation to cognitive outcomes.

Adolescent Police Stops, Self-Harm, and Attempted Suicide: Findings From the UK Millennium Cohort Study, 2012‒2019

Objectives. To explore associations between police stops, self-harm, and attempted suicide among a large, representative sample of adolescents in the United Kingdom. Methods. Data were drawn from the 3 most recent sweeps of the UK Millennium Cohort Study (MCS), from 2012 to 2019. The MCS is an ongoing nationally representative contemporary birth cohort of children born in the United Kingdom between September 2000 and January 2002 (n = 10 345). Weights were used to account for sample design and multiple imputation for missing data. Results. Youths experiencing police stops by the age of 14 years (14.77%) reported significantly higher rates of self-harm (incidence rate ratio = 1.52; 95% confidence interval [CI] = 1.35, 1.69) at age 17 years and significantly higher odds of attempted suicide (odds ratio = 2.25; 95% CI = 1.84, 2.76) by age 17 years. These patterns were largely consistent across examined features of police stops and generally did not vary by sociodemographic factors. In addition, 17.73% to 40.18% of associations between police stops and outcomes were explained by mental distress. Conclusions. Police-initiated encounters are associated with youth self-harm and attempted suicide. Youths may benefit when school counselors or social workers provide mental health screenings and offer counseling care following these events. (Am J Public Health. Published online ahead of print September 23, 2021: e1–e9. https://doi.org/10.2105/AJPH.2021.306434 )

Late adolescent outcomes of different developmental trajectories of ADHD symptoms in a large longitudinal study

Background: There exists substantial heterogeneity in the developmental trajectories of ADHD symptoms, with distinctions often made between persistent versus remittent, and early- versus late-onset. However, how these trajectories relate to late adolescent functioning and whether, in particular, later onset trajectories mark a milder subtype remains unclear. Methods: We applied latent class growth analysis to data from the UK Millennium Cohort Study (N = 16,703) to evaluate whether developmental trajectories of ADHD symptoms (ages 3-17) were associated with differing levels of impairment in peer problems, mental health, substance use, and delinquency at age 17. Results: Our optimal model included five trajectory groups, labelled unaffected (37.6%), mildly affected (34.8%), subclinical remitting (14.4%), adolescent onset (7.6%), and stable high (5.6%). Adolescent onset and stable high trajectories were similarly impaired across all outcomes, other than substance use. Subclinical remitting individuals were impaired on self-esteem and well-being compared to unaffected individuals. Conclusions: By adolescence, those with a later onset have similar impairments to those following an early onset/persistent trajectory. Residual impairment remains for those on a remitting trajectory.