Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats

Julian Ott; Mona M. Spilhaug; Simone Maschauer; Waqas Rafique; Jimmy E. Jakobsson; Karoline Hartvig; Harald Hübner; Peter Gmeiner; Olaf Prante; Patrick J. Riss

doi:10.1021/acs.jmedchem.0c00683

Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00683 ◽

2020 ◽

Vol 63 (17) ◽

pp. 9484-9499

Author(s):

Julian Ott ◽

Mona M. Spilhaug ◽

Simone Maschauer ◽

Waqas Rafique ◽

Jimmy E. Jakobsson ◽

...

Keyword(s):

Brain Imaging ◽

Opioid Receptor ◽

Pharmacological Characterization ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Pharmacological Characterization of Kappa Opioid Receptor Agonists

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.663.14 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Sophia Kaska ◽

Lindsay Kornberger ◽

Andrew Biggerstaff ◽

Bronwyn Kivell ◽

Thomas Prisinzano

Keyword(s):

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Pharmacological Characterization ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

Scientific Reports ◽

10.1038/s41598-020-70493-1 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Teresa Kaserer ◽

Theresa Steinacher ◽

Roman Kainhofer ◽

Filippo Erli ◽

Sonja Sturm ◽

...

Keyword(s):

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Receptor Agonists ◽

Opioid Receptor Agonists ◽

Identification And Characterization

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Characterization of the discriminative stimulus effects of binary mixtures of mu opioid receptor agonists in rats discriminating fentanyl

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.121.000912 ◽

2021 ◽

pp. JPET-AR-2021-000912

Author(s):

Shawn M Flynn ◽

Charles P. France

Keyword(s):

Binary Mixtures ◽

Opioid Receptor ◽

Discriminative Stimulus ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Receptor Agonists ◽

Discriminative Stimulus Effects ◽

Stimulus Effects ◽

Opioid Receptor Agonists

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Promising Therapeutic Agents: Delta Opioid Receptor Agonists

The International Annals of Medicine ◽

10.24087/iam.2017.1.8.252 ◽

2017 ◽

Vol 1 (8) ◽

Author(s):

Amjad Hasan Bazzari ◽

Firas Hasan Bazzari

Keyword(s):

Opioid Receptor ◽

Therapeutic Agents ◽

Delta Opioid Receptor ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Faculty Opinions recommendation of Abuse potential of biased mu opioid receptor agonists.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734246147.793553258 ◽

2018 ◽

Author(s):

David Taylor

Keyword(s):

Opioid Receptor ◽

Mu Opioid Receptor ◽

Abuse Potential ◽

Mu Opioid ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Cover Feature: Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists (12/2021)

ChemMedChem ◽

10.1002/cmdc.202100380 ◽

2021 ◽

Vol 16 (12) ◽

pp. 1834-1834

Author(s):

Veena D. Yadav ◽

Lalan Kumar ◽

Poonam Kumari ◽

Sakesh Kumar ◽

Maninder Singh ◽

...

Keyword(s):

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences ◽

10.1254/jphs.scj05006x ◽

2006 ◽

Vol 100 (2) ◽

pp. 157-161 ◽

Cited By ~ 14

Author(s):

Tomohisa Mori ◽

Mutsuko Nomura ◽

Kazumi Yoshizawa ◽

Hiroshi Nagase ◽

Toshiko Sawaguchi ◽

...

Keyword(s):

Nmda Receptor ◽

Opioid Receptor ◽

Discriminative Stimulus ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Discriminative Stimulus Effects ◽

Stimulus Effects ◽

Opioid Receptor Agonists

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Mechanisms Responsible for the Enhanced Antinociceptive Effects of μ-Opioid Receptor Agonists in the Rostral Ventromedial Medulla of Male Rats with Persistent Inflammatory Pain

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.121954 ◽

2007 ◽

Vol 322 (2) ◽

pp. 813-821 ◽

Cited By ~ 25

Author(s):

Kenneth T. Sykes ◽

Stephanie R. White ◽

Robert W. Hurley ◽

Hirokazu Mizoguchi ◽

Leon F. Tseng ◽

...

Keyword(s):

Opioid Receptor ◽

Inflammatory Pain ◽

Male Rats ◽

Rostral Ventromedial Medulla ◽

Receptor Agonists ◽

Antinociceptive Effects ◽

Ventromedial Medulla ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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The effect of intrathecal opioid-receptor agonists on visceral noxious stimulation in rabbits

Gastroenterology ◽

10.1053/gast.1996.v110.pm8536850 ◽

1996 ◽

Vol 110 (1) ◽

pp. 139-146 ◽

Cited By ~ 16

Author(s):

FM Borgbjerg ◽

C Frigast ◽

JB Madsen ◽

LF Mikkelsen

Keyword(s):

Opioid Receptor ◽

Noxious Stimulation ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.03.020 ◽

2005 ◽

Vol 15 (10) ◽

pp. 2647-2652 ◽

Cited By ~ 11

Author(s):

Bertrand Le Bourdonnec ◽

Christopher W. Ajello ◽

Pamela R. Seida ◽

Roberta G. Susnow ◽

Joel A. Cassel ◽

...

Keyword(s):

Cytochrome P450 ◽

Opioid Receptor ◽

Inhibitory Activity ◽

Cytochrome P450 2D6 ◽

Receptor Agonists ◽

Opioid Receptor Agonists ◽

P450 2D6

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