Generating Selective Leads for Mer Kinase Inhibitors—Example of a Comprehensive Lead-Generation Strategy

2021 ◽  
Author(s):  
J. Willem M. Nissink ◽  
Sana Bazzaz ◽  
Carolyn Blackett ◽  
Matthew A. Clark ◽  
Olga Collingwood ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Lead Generation ◽  
Mer Kinase Inhibitors

Correction to Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

2014 ◽  
Vol 57 (16) ◽  
pp. 7141-7141
Author(s):  
Weihe Zhang ◽  
Dehui Zhang ◽  
Michael A. Stashko ◽  
Deborah DeRyckere ◽  
Debra Hunter ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Intramolecular Hydrogen Bond ◽  
Kinase Inhibitors ◽  
Intramolecular Hydrogen ◽  
Mer Kinase Inhibitors

scholarly journals Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

2012 ◽  
Vol 3 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Jing Liu ◽  
Chao Yang ◽  
Catherine Simpson ◽  
Deborah DeRyckere ◽  
Amy Van Deusen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Small Molecule ◽  
Kinase Inhibitors ◽  
Lymphoblastic Leukemia ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
Mer Kinase Inhibitors

3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines

2014 ◽  
Vol 19 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Zhuang Yu ◽  
Xianchao Li ◽  
Cuizhu Ge ◽  
Hongzong Si ◽  
Lianhua Cui ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Kinase Inhibitors ◽  
3D Qsar ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Qsar Modeling ◽  
Mer Kinase Inhibitors

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

2005 ◽  
Vol 48 (2) ◽  
pp. 414-426 ◽  
Author(s):  
Adrian L. Gill ◽  
Martyn Frederickson ◽  
Anne Cleasby ◽  
Steven J. Woodhead ◽  
Maria G. Carr ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Lead Generation ◽  
P38α Map Kinase

scholarly journals Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

2013 ◽  
Vol 56 (23) ◽  
pp. 9683-9692 ◽  
Author(s):  
Weihe Zhang ◽  
Dehui Zhang ◽  
Michael A. Stashko ◽  
Deborah DeRyckere ◽  
Debra Hunter ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Intramolecular Hydrogen Bond ◽  
Kinase Inhibitors ◽  
Intramolecular Hydrogen ◽  
Mer Kinase Inhibitors

Structure Guided Lead Generation toward NonchiralM. tuberculosisThymidylate Kinase Inhibitors

2018 ◽  
Vol 61 (7) ◽  
pp. 2753-2775 ◽  
Author(s):  
Lijun Song ◽  
Romain Merceron ◽  
Begoña Gracia ◽  
Ainhoa Lucía Quintana ◽  
Martijn D. P. Risseeuw ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Lead Generation
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