scholarly journals Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

2021 ◽  
Author(s):  
Ana Mallo-Abreu ◽  
Irene Reyes-Resina ◽  
Jhonny Azuaje ◽  
Rafael Franco ◽  
Aitor García-Rey ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Partial Agonists ◽  
Dopamine D2 ◽  
Subtype Selective ◽  
Selective Dopamine

ChemInform Abstract: New 2-Thioether-Substituted Apomorphines as Potent and Selective Dopamine D2 Receptor Agonists.

ChemInform ◽  
2011 ◽  
Vol 42 (41) ◽  
pp. no-no
Author(s):  
Reet Reinart ◽  
Zsuzsanna Gyulai ◽  
Sandor Berenyi ◽  
Sandor Antus ◽  
Argo Vonk ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Agonists ◽  
Dopamine D2 ◽  
Selective Dopamine

An attempt at the hydrated imidazoline ring expansion (HIRE) of diarene-fused [1,4]diazepinones delivers selective dopamine D2 receptor ligands

Synthesis ◽  
2021 ◽  
Author(s):  
Sergey Grintsevich ◽  
Alexander V. Sapegin ◽  
Andrzej Bojarski ◽  
Beata Duszyńska ◽  
Mikhail Krasavin
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Ring Expansion ◽  
Side Chain ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Dopamine D2 ◽  
Structure Activity ◽  
Imidazoline Ring ◽  
Selective Dopamine

Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) resulted in no ring expansion but rather 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure-activity relationships.

Remoxipride, a selective dopamine D2 receptor antagonist, in tardive dyskinesia

1988 ◽  
Vol 94 (2) ◽  
Author(s):  
Ulf Andersson ◽  
Jan-Erik H�ggstr�m ◽  
Maj-Inger Nilsson ◽  
Erik Widerl�v
Keyword(s):  
Tardive Dyskinesia ◽  
Receptor Antagonist ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Selective Dopamine ◽  
Dopamine D2 Receptor Antagonist

scholarly journals Active-State Model of a Dopamine D2 Receptor - Gαi Complex Stabilized by Aripiprazole-Type Partial Agonists

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100069 ◽  
Author(s):  
Ralf C. Kling ◽  
Nuska Tschammer ◽  
Harald Lanig ◽  
Timothy Clark ◽  
Peter Gmeiner
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Active State ◽  
State Model ◽  
Partial Agonists ◽  
Dopamine D2
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