Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases

Fibrotic Diseases

The Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation

10.26226/morressier.59b63e3fd462b8029238929e ◽

2017 ◽

Author(s):

Kazuyuki Sakamoto

Keyword(s):

Cell Proliferation ◽

Receptor Antagonist ◽

Lysophosphatidic Acid ◽

Prostate Cell ◽

Acid Receptor ◽

Urethral Function

Faculty Opinions recommendation of The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1103139.559129 ◽

2008 ◽

Author(s):

Michael Pillinger

Keyword(s):

Pulmonary Fibrosis ◽

Lung Injury ◽

Lysophosphatidic Acid ◽

Vascular Leak ◽

Acid Receptor ◽

Interaction of the SARS-COV2 Envelope Protein (E) with Lysophosphatidic Acid Receptor 1 (LPAR1) and Additional Human Proteins Involved in Inflammation, Immunity, ADP Ribosylation and Vesicular Transport

SSRN Electronic Journal ◽

10.2139/ssrn.3701791 ◽

2020 ◽

Author(s):

Girish Nallur

Keyword(s):

Lysophosphatidic Acid ◽

Envelope Protein ◽

Vesicular Transport ◽

Acid Receptor ◽

Adp Ribosylation ◽

Human Proteins

A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid‐induced cellular responses

Journal of Cellular Biochemistry ◽

10.1002/jcb.29919 ◽

2021 ◽

Author(s):

Sarah J Taleb ◽

Jianxin Wei ◽

Rachel K Mialki ◽

Su Dong ◽

Yanhui Li ◽

...

Keyword(s):

Lysophosphatidic Acid ◽

Cellular Responses ◽

Acid Receptor ◽

A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/j.bbamcr.2007.11.013 ◽

2008 ◽

Vol 1783 (5) ◽

pp. 748-759 ◽

Cited By ~ 51

Author(s):

Shinya Shano ◽

Kazuki Hatanaka ◽

Shinsuke Ninose ◽

Ryutaro Moriyama ◽

Toshifumi Tsujiuchi ◽

...

Keyword(s):

Cell Proliferation ◽

Lysophosphatidic Acid ◽

Binding Domain ◽

Acid Receptor ◽

Constitutively Active

Lysophosphatidic acid receptor 1 (LPAR1; EDG2; LPA1)

Science-Business eXchange ◽

10.1038/scibx.2011.1049 ◽

2011 ◽

Vol 4 (37) ◽

pp. 1049-1049

Keyword(s):

Lysophosphatidic Acid ◽

Acid Receptor ◽

The status of the lysophosphatidic acid receptor type 1 (LPA1R)

MedChemComm ◽

10.1039/c4md00333k ◽

2015 ◽

Vol 6 (1) ◽

pp. 13-23 ◽

Cited By ~ 9

Author(s):

Inés González-Gil ◽

Debora Zian ◽

Henar Vázquez-Villa ◽

Silvia Ortega-Gutiérrez ◽

María L. López-Rodríguez

Keyword(s):

Drug Development ◽

Lysophosphatidic Acid ◽

Receptor Type ◽

Current Status ◽

Acid Receptor ◽

The Status ◽

Development Pipeline

The current status of the LPA1receptor and its ligands in the drug development pipeline is reviewed.

Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

International Journal of Oncology ◽

10.3892/ijo.2011.1309 ◽

2011 ◽

Vol 40 (4) ◽

pp. 1133-1141 ◽

Cited By ~ 37

Author(s):

MARION DAVID ◽

JOHNNY RIBEIRO ◽

FRANÇOISE DESCOTES ◽

CLAIRE-MARIE SERRE ◽

MARYSE BARBIER ◽

...

Keyword(s):

Breast Cancer ◽

Cell Proliferation ◽

Cancer Cells ◽

Lysophosphatidic Acid ◽

Breast Cancer Cells ◽

Receptor Type ◽

Spontaneous Metastasis ◽

Acid Receptor ◽

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

Molecular and Cellular Neuroscience ◽

10.1016/j.mcn.2008.07.014 ◽

2008 ◽

Vol 39 (3) ◽

pp. 342-355 ◽

Cited By ~ 76

Author(s):

Elisa Matas-Rico ◽

Beatriz García-Diaz ◽

Pedro Llebrez-Zayas ◽

Diana López-Barroso ◽

Luis Santín ◽

...

Keyword(s):

Dentate Gyrus ◽

Lysophosphatidic Acid ◽

Acid Receptor ◽

274 MECHANISM OF BLADDER HYPERPLASIA LEADING TO DETRUSOR DYSFUNCTION: INVOLVEMENT OF LYSOPHOSPHATIDIC ACID RECEPTOR 1

The Journal of Urology ◽

10.1016/j.juro.2013.02.1658 ◽

2013 ◽

Vol 189 (4S) ◽

Author(s):

Yohei Kawashima ◽

Nobuhiro Kushida ◽

Soichiro Ogawa ◽

Masao Kataoka ◽

Norio Takahashi ◽

...

Keyword(s):

Lysophosphatidic Acid ◽

Acid Receptor ◽