scholarly journals Effect of α-Methyl versus α-Hydrogen Substitution on Brain Availability and Tumor Imaging Properties of Heptanoic [F-18]Fluoroalkyl Amino Acids for Positron Emission Tomography (PET)

2016 ◽  
Vol 59 (7) ◽  
pp. 3515-3531 ◽  
Author(s):  
Ahlem Bouhlel ◽  
Wadha Alyami ◽  
Aixiao Li ◽  
Liya Yuan ◽  
Keith Rich ◽  
...  
Keyword(s):  
Amino Acids ◽  
Positron Emission Tomography ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Positron Emission ◽  
Hydrogen Substitution ◽  
Imaging Properties

BRAIN TUMOR IMAGING BASED ON C-11 LABELED AMINO ACID UTILIZATION USING POSITRON EMISSION TOMOGRAPHY

1980 ◽  
Vol 15 (5) ◽  
pp. 380
Author(s):  
C Leon Partain ◽  
Karl F. Hubner ◽  
M. Stephen Mahaley ◽  
F. David Rollo ◽  
Ronald R. Price ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tumor ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Positron Emission ◽  
Amino Acid Utilization

scholarly journals Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Han Feng ◽  
Xiaobo Wang ◽  
Jian Chen ◽  
Jing Cui ◽  
Tang Gao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Tumor Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Nuclear Imaging ◽  
Emission Tomography ◽  
Metabolic Imaging ◽  
Emission Computed Tomography ◽  
Positron Emission

Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[18F]fluoro-glucose (18F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of 18F-FDG has prompted intensive research efforts into other glucose-based radiopharmaceuticals for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging. Currently, glucose and its analogues have been labeled with various radionuclides such as 99mTc, 111In, 18F, 68Ga, and 64Cu and have been successfully investigated for tumor metabolic imaging in many preclinical studies. Moreover, 99mTc-ECDG has advanced into its early clinical trials and brings a new era of tumor imaging beyond 18F-FDG. In this review, preclinical and early clinical development of glucose-based radiopharmaceuticals for tumor metabolic imaging will be summarized.

Preclinical and clinical evaluation of O-[11C]methyl-l-tyrosine for tumor imaging by positron emission tomography

2005 ◽  
Vol 32 (3) ◽  
pp. 253-262 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Hideo Tsukada ◽  
Kazuo Kubota ◽  
Tadashi Nariai ◽  
Norihiro Harada ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Clinical Evaluation ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Positron Emission

Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography

2010 ◽  
Vol 18 (21) ◽  
pp. 7338-7347 ◽  
Author(s):  
Dinesh Shetty ◽  
Jae Min Jeong ◽  
Chang Hwan Ju ◽  
Young Ju Kim ◽  
Ji-Youn Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Amino Acid Derivatives ◽  
Positron Emission ◽  
Gallium 68
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