scholarly journals Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

2017 ◽  
Vol 80 (5) ◽  
pp. 1339-1346 ◽  
Author(s):  
Marianna Carbone ◽  
M. Letizia Ciavatta ◽  
Véronique Mathieu ◽  
Aude Ingels ◽  
Robert Kiss ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Synthetic Analogues ◽  
Naturally Occurring ◽  
Structure Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Febrifugine Analogues

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Huong Doan Thi Mai ◽  
Giang Vo Thanh ◽  
Van Hieu Tran ◽  
Van Nam Vu ◽  
Van Loi Vu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Strong Inhibition ◽  
Synthetic Analogues ◽  
Synthetic Compounds ◽  
Activity Evaluation ◽  
Synthesis And Biological Evaluation

A series of febrifugine analogues were designed and synthesized. Antimalarial activity evaluation of the synthetic compounds indicated that these derivatives had a strong inhibition against both chloroquine-sensitive and -resistant Plasmodium falciparum parasites. Many of them were found to be more active than febrifugine hydrochloride. The tested analogues had also a significant cytotoxicity against four cancer cell lines (KB, MCF7, LU1 and HepG2). Among the synthetic analogues, two compounds 17b and 17h displayed a moderate cytotoxicity while they exhibited a remarkable antimalarial activity.

Synthesis and Biological Evaluation of a Natural Ester Sintenin and Its Synthetic Analogues

2005 ◽  
Vol 68 (3) ◽  
pp. 342-348 ◽  
Author(s):  
Li Hong Hu ◽  
Hong Bin Zou ◽  
Jing Xu Gong ◽  
Hai Bo Li ◽  
Lei Xiang Yang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Synthetic Analogues ◽  
Synthesis And Biological Evaluation ◽  
Natural Ester

Synthesis and Biological Evaluation of Isomeric Derivatives of Naturally Occurring Spatozoate.

ChemInform ◽  
2006 ◽  
Vol 37 (38) ◽  
Author(s):  
Safdar Hayat ◽  
Atta-ur-Rahman Atta-ur-Rahman ◽  
Muhammad Iqbal Choudhary ◽  
Khalid Mohammed Khan ◽  
Shahnaz Perveen ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Naturally Occurring ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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