Application of Oxidative and Reductive Transformations in the Structure Determination of Marine Natural Products

2020 ◽  
Vol 83 (4) ◽  
pp. 1314-1333
Author(s):  
Tatyana N. Makarieva ◽  
Natalia V. Ivanchina ◽  
Valentin A. Stonik
Keyword(s):  
Natural Products ◽  
Structure Determination ◽  
Marine Natural Products

Single Crystal X-Ray Structural Determination: A Powerful Technique for Natural Products Research and Drug Discovery

2012 ◽  
Vol 545 ◽  
pp. 3-15
Author(s):  
Hoong Kun Fun ◽  
Suchada Chantrapromma ◽  
Nawong Boonnak
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Single Crystal ◽  
Natural Product ◽  
Structure Determination ◽  
Three Dimensional ◽  
X Ray ◽  
Powerful Technique ◽  
Determination Of Absolute Configuration

Drug discovery from natural products resources have been extensively studied. The most important step in the discovery process is the identification of compounds with interesting biological activity. Single crystal X-ray structure determination is a powerful technique for natural products research and drug discovery in which the detailed three-dimensional structures that emerge can be co-related to the activities of these structures. This article shall present (i) co-crystal structures, (ii) determination of absolute configuration and (iii) the ability to distinguish between whether a natural product compound is a natural product or a natural product artifact. All these three properties are unique to the technique of single crystal X-ray structure determination.

Strategies and Tools for Structure Determination of Natural Products Using Modern Methods of NMR Spectroscopy

ChemInform ◽  
2005 ◽  
Vol 36 (47) ◽  
Author(s):  
Bross-Walch Nadja ◽  
Till Kuehn ◽  
Detlef Moskau ◽  
Oliver Zerbe
Keyword(s):  
Natural Products ◽  
Nmr Spectroscopy ◽  
Structure Determination ◽  
Modern Methods

The structure determination of two related eremophilone dimers

1982 ◽  
Vol 35 (4) ◽  
pp. 809 ◽  
Author(s):  
DE Lewis ◽  
RA Massy-Westropp ◽  
CF Ingham ◽  
RJ Wells
Keyword(s):  
Natural Products ◽  
Structure Determination ◽  
Carbon Skeleton ◽  
X Ray ◽  
New Class

The first representatives of a new class of eremophilone dimers have been isolated from the wood oil of Eremophila mitchelli and shown by a combination of spectroscopic and X-ray techniques to possess the unusual 1-(8',8'a-dimethylperhydronaphthalen-2'-yl)-1,4,5,10a-tetramethylperhydroanthracene carbon skeleton. These two natural products are the first C30 compounds to be isolated from any member of the genus Eremophila.

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