scholarly journals Physical Chemistry of the Protein Backbone: Enabling the Mechanisms of Intrinsic Protein Disorder

2020 ◽  
Vol 124 (22) ◽  
pp. 4379-4390
Author(s):  
Justin A. Drake ◽  
B. Montgomery Pettitt
Keyword(s):  
Physical Chemistry ◽  
Protein Disorder ◽  
Protein Backbone ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder

scholarly journals Origins of Myc Proteins – Using Intrinsic Protein Disorder to Trace Distant Relatives

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75057 ◽  
Author(s):  
Amir Mahani ◽  
Johan Henriksson ◽  
Anthony P. H. Wright
Keyword(s):  
Protein Disorder ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder

scholarly journals Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges

2020 ◽  
Vol 26 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Jesús Alejandro Zamora-Briseño ◽  
Alejandro Pereira-Santana ◽  
Sandi Julissa Reyes-Hernández ◽  
Daniel Cerqueda-García ◽  
Enrique Castaño ◽  
...  
Keyword(s):  
Protein Disorder ◽  
Plant Adaptation ◽  
Environmental Challenges ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder

scholarly journals Intrinsic protein disorder in histone lysine methylation

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Tamas Lazar ◽  
Eva Schad ◽  
Beata Szabo ◽  
Tamas Horvath ◽  
Attila Meszaros ◽  
...  
Keyword(s):  
Protein Disorder ◽  
Lysine Methylation ◽  
Intrinsic Protein ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Intrinsic Protein Disorder

scholarly journals Intrinsic protein disorder in human pathways

2012 ◽  
Vol 8 (1) ◽  
pp. 320-326 ◽  
Author(s):  
Jessica H. Fong ◽  
Benjamin A. Shoemaker ◽  
Anna R. Panchenko
Keyword(s):  
Protein Disorder ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder

scholarly journals Structural propensity database of proteins

2017 ◽  
Author(s):  
Kamil Tamiola ◽  
Matthew M Heberling ◽  
Jan Domanski
Keyword(s):  
Structural Dynamics ◽  
Protein Function ◽  
Chemical Shifts ◽  
Protein Disorder ◽  
Computational Biophysics ◽  
Intrinsic Protein ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Regions ◽  
Intrinsic Protein Disorder ◽  
Structural Insights

AbstractAn overwhelming amount of experimental evidence suggests that elucidations of protein function, interactions, and pathology are incomplete without inclusion of intrinsic protein disorder and structural dynamics. Thus, to expand our understanding of intrinsic protein disorder, we have created a database of secondary structure (SS) propensities for proteins (dSPP) as a reference resource for experimental research and computational biophysics. The dSPP comprises SS propensities of 7,094 unrelated proteins, as gauged from NMR chemical shift measurements in solution and solid state. Here, we explain the concept of SS propensity and analyze dSPP entries of therapeutic relevance, α-synuclein, MOAG-4, and the ZIKA NS2B-NS3 complex to show: (1) how propensity mapping generates novel structural insights into intrinsically disordered regions of pathologically relevant proteins, (2) how computational biophysics tools can benefit from propensity mapping, and (3) how the residual disorder estimation based on NMR chemical shifts compares with sequence-based disorder predictors. This work demonstrates the benefit of propensity estimation as a method that reports both on protein structure, lability, and disorder.

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

2009 ◽  
Vol 138 (1) ◽  
pp. 198-208
Author(s):  
Tanya Vavouri ◽  
Jennifer I. Semple ◽  
Rosa Garcia-Verdugo ◽  
Ben Lehner
Keyword(s):  
Protein Disorder ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder ◽  
Dosage Sensitivity

scholarly journals Understanding the penetrance of intrinsic protein disorder in rotavirus proteome

2020 ◽  
Vol 144 ◽  
pp. 892-908 ◽  
Author(s):  
Deepak Kumar ◽  
Ankur Singh ◽  
Prateek Kumar ◽  
Vladimir N. Uversky ◽  
C. Durga Rao ◽  
...  
Keyword(s):  
Protein Disorder ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder

Comprehensive large-scale assessment of intrinsic protein disorder

2014 ◽  
Vol 31 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Ian Walsh ◽  
Manuel Giollo ◽  
Tomás Di Domenico ◽  
Carlo Ferrari ◽  
Olav Zimmermann ◽  
...  
Keyword(s):  
Large Scale ◽  
Protein Disorder ◽  
Intrinsic Protein ◽  
Large Scale Assessment ◽  
Scale Assessment ◽  
Intrinsic Protein Disorder

Intrinsic protein disorder in oncogenic KRAS signaling

2017 ◽  
Vol 74 (17) ◽  
pp. 3245-3261 ◽  
Author(s):  
Ruth Nussinov ◽  
Hyunbum Jang ◽  
Chung-Jung Tsai ◽  
Tsung-Jen Liao ◽  
Shuai Li ◽  
...  
Keyword(s):  
Protein Disorder ◽  
Intrinsic Protein ◽  
Intrinsic Protein Disorder
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