Theoretical Insights into the Role of Water Molecules in the Guanidinium-Based Protein Denaturation Process in Specific to Aromatic Amino Acids

2019 ◽  
Vol 123 (10) ◽  
pp. 2191-2202 ◽  
Author(s):  
Kanagasabai Balamurugan ◽  
Muthuramalingam Prakash ◽  
Venkatesan Subramanian
Keyword(s):  
Amino Acids ◽  
Protein Denaturation ◽  
Aromatic Amino Acids ◽  
Water Molecules ◽  
Denaturation Process

Combined DFT and MD simulation studies of protein stability on imidazolium–water (ImH+Wn) clusters with aromatic amino acids

2020 ◽  
Vol 44 (41) ◽  
pp. 17912-17923
Author(s):  
Kandhan Palanisamy ◽  
Muthuramalingam Prakash ◽  
Varatharaj Rajapandian
Keyword(s):  
Amino Acids ◽  
Protein Stability ◽  
Md Simulation ◽  
Protein Denaturation ◽  
Aromatic Amino Acids ◽  
Simulation Studies ◽  
Π Stacking ◽  
Hydrated Clusters

The hydrated clusters of protonated imidazole (ImH+) can induce protein denaturation through various kinds of monovalent interactions such as cation···π (stacking), N–H⋯π (T-shaped) and water-mediated O–H⋯O H-bonds.

Chain Elongation of Aromatic Amino Acids: the Role of 2-Benzylmalic Acid in the Biosynthesis of a C6C4 Amino Acid and a C6C3 Mustard Oil Glucoside

1974 ◽  
Vol 52 (10) ◽  
pp. 916-921 ◽  
Author(s):  
D. Dörnemann ◽  
W. Löffelhardt ◽  
H. Kindl
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aromatic Amino Acids ◽  
Chain Elongation ◽  
Mustard Oil ◽  
Barbarea Vulgaris ◽  
Nasturtium Officinale ◽  
A Chain ◽  
Phenylbutyric Acid

A chemical synthesis of specifically 14C-labelled 2-benzylmalic acid, hitherto unknown, was developed. 4-Phenylacetoacetate obtained by condensation of phenylacetyl chloride-1-14C with ethyl acetoacetate yielded 2-benzylmalic acid-2-14C after cyanohydrin reaction and hydrolysis.2-Benzylmalic acid-2-14C, administered to shoots of Nasturtium officinale and Barbarea vulgaris, was shown to be an efficient precursor of the aglucone moiety of the mustard oil glucoside gluconasturtiin. The incorporation of radioactivity agreed well with the values reported for incorporation of 3-benzylmalic acid, but was considerably higher than that obtained after application of L-phenylalanine-U-14C. A conversion of 2-benzylmalic acid into 3-benzylmalic acid and 2-amino-4-phenylbutyric acid could also be demonstrated. These findings provide the final evidence for a chain-lengthening mechanism leading to homologous amino acids as proposed by Underbill and Wetter in 1966.

scholarly journals Role of Aromatic Amino Acids in Carbohydrate Binding. Laser Photo CIDNP(Chemically Induced Dynamic Nuclear Polarisation) and Molecular Modeling Study of Hevein-domain Containing Lectins

1996 ◽  
Vol 2 (9) ◽  
pp. 351-353 ◽  
Author(s):  
Hans-Christian Siebert ◽  
Claus-Wilhelm von der Lieth ◽  
Robert Kaptein ◽  
Ukun M. S. Soedjanaatmadja ◽  
Johannes F. G. Vliegenthart ◽  
...  
Keyword(s):  
Amino Acids ◽  
Molecular Modeling ◽  
Aromatic Amino Acids ◽  
Carbohydrate Binding ◽  
Dynamic Nuclear Polarisation ◽  
Nuclear Polarisation ◽  
Molecular Modeling Study ◽  
Chemically Induced ◽  
Modeling Study

Role of Acidic and Aromatic Amino Acids inRhodobacter CapsulatusCytochromec1. A Site-Directed Mutagenesis Study†

Biochemistry ◽  
2003 ◽  
Vol 42 (29) ◽  
pp. 8818-8830 ◽  
Author(s):  
Jun Li ◽  
Artur Osyczka ◽  
Richard C. Conover ◽  
Michael K. Johnson ◽  
Hong Qin ◽  
...  
Keyword(s):  
Amino Acids ◽  
Aromatic Amino Acids ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
A Site ◽  
Mutagenesis Study

Order controls disordered droplets: structure-function relationships in C9orf72-derived poly(PR)

2021 ◽  
Author(s):  
Kohsuke Kanekura ◽  
Yuhei Hayamizu ◽  
Masahiko Kuroda
Keyword(s):  
Amino Acids ◽  
Aromatic Amino Acids ◽  
Polar Amino Acid ◽  
Repeat Proteins ◽  
Intron 1 ◽  
Lateral Sclerosis ◽  
Ran Translation ◽  
Dipeptide Repeat ◽  
Positively Charged

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have been thought as two distinct neurodegenerative diseases. However, recent genetic screening and careful investigations found the genetic and pathological overlap among these disorders. Hexanucleotide expansions in intron 1 of C9orf72 are a leading cause of familial ALS and familial FTD. These expansions facilitate the repeat-associated non-ATG initiated translation (RAN translation), producing five dipeptide repeat proteins (DRPs), including Arg-rich poly(PR: Pro-Arg) and poly-(GR: Gly-Arg) peptides. Arg is a positively charged, highly polar amino acid that facilitates interactions with anionic molecules such as nucleic acids and acidic amino acids via electrostatic forces and aromatic amino acids via cation-pi interaction, suggesting that Arg-rich DRPs underlie the pathophysiology of ALS via Arg-mediated molecular interactions. Arg-rich DRPs have also been reported to induce neurodegeneration in cellular and animal models via multiple mechanisms; however, it remains unclear why the Arg-rich DRPs exhibit such diverse toxic properties, because not all Arg-rich peptides are toxic. In this mini-review, we discuss the current understanding of the pathophysiology of Arg-rich C9orf72 DRPs and introduce recent findings on the role of Arg distribution as a determinant of the toxicity and its contribution to the pathogenesis of ALS.

The role of branched-chain amino acids and aromatic amino acids of various tissues and the degenerations of skeletal muscle fiber in liver cirrhosis model rat

2000 ◽  
Vol 118 (4) ◽  
pp. A773
Author(s):  
Yasushi Matsuzaki ◽  
Teruo Miyazaki ◽  
Masaaki Karube ◽  
Norio Ogoshi ◽  
Syunpei Miyakawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Liver Cirrhosis ◽  
Muscle Fiber ◽  
Aromatic Amino Acids ◽  
Branched Chain Amino Acids ◽  
Skeletal Muscle Fiber ◽  
Branched Chain

Role of aromatic amino acids in pathogeneses of diabetic nephropathy in Chinese patients with type 2 diabetes

2020 ◽  
Vol 34 (10) ◽  
pp. 107667
Author(s):  
Shiti Zhang ◽  
Xin Li ◽  
Huihuan Luo ◽  
Zhong-Ze Fang ◽  
Hao Ai
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acids ◽  
Diabetic Nephropathy ◽  
Aromatic Amino Acids ◽  
Chinese Patients
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