Plasma Metabolomic Changes in Children with Cerebral Palsy Exposed to Botulinum Neurotoxin

2022 ◽  
Author(s):  
Hongmei Tang ◽  
Tingting Peng ◽  
Xubo Yang ◽  
Liru Liu ◽  
Yunxian Xu ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Botulinum Neurotoxin ◽  
Children With Cerebral Palsy

scholarly journals Adverse drug reactions of botulinum neurotoxin type A in children with cerebral palsy: a pharmaco-epidemiological study in VigiBase

2016 ◽  
Vol 59 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Jeanne Montastruc ◽  
Philippe Marque ◽  
Florence Moulis ◽  
Véronique Bourg ◽  
Valérie Lambert ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Epidemiological Study ◽  
Adverse Drug Reactions ◽  
Botulinum Neurotoxin ◽  
Type A ◽  
Drug Reactions ◽  
Botulinum Neurotoxin Type A ◽  
Children With Cerebral Palsy

Functional outcomes of botulinum neurotoxin-A injection followed by reciprocal electrical stimulation in children with cerebral palsy: A randomized controlled trial

2020 ◽  
pp. 1-11
Author(s):  
Ragab K. Elnaggar ◽  
Bader A. Alqahtani ◽  
Mohammed F. Elbanna
Keyword(s):  
Cerebral Palsy ◽  
Electrical Stimulation ◽  
Botulinum Neurotoxin ◽  
Hand Function ◽  
Botulinum Neurotoxin A ◽  
Group Iii ◽  
Children With Cerebral Palsy ◽  
Spastic Hemiplegia ◽  
Upper Extremity Function

Background: The integration of therapeutic approaches is increasingly recommended for children with cerebral palsy, to enhance outcomes. Nevertheless, clinicians still opt for separate or combined therapies based on little credible knowledge. Objective: This study endeavored to evaluate the effect of botulinum neurotoxin-A (BoNT-A) injection and reciprocal neuromuscular electrical stimulation (rNMES) and their combination on the upper extremity function in children with spastic hemiplegia. Methods: Sixty-four children with spastic hemiplegia (aged 6– 10 years) were randomly assigned to four treatment-based groups [group I (BoNT-A), group II (rNMES), group III (combined BoNT-A and rNMES), and group IV (Control)]. All children received a physical rehabilitation program, thrice/week over three months. Unilateral upper-limb function, bimanual hand function, and real-time arm-hand function were assessed using Melbourne Assessment (MA), Assisting Hand Assessment (AHA), and Pediatric Motor Activity Log (PMAL) scales respectively pre-treatment, post-treatment, and at 6 months follow-up. Results: Post-treatment, group III achieved greater improvement in MA, AHA, and PMAL compared to other groups (all P <  0.05), and the difference remained in favor of group III at the follow-up (all P <  0.05). Conclusions: This study suggests that BoNT-A and rNMES combined are more effective than either of them alone to enhance upper-extremity function in children with spastic hemiplegia.

Combining strength training and botulinum neurotoxin intervention in children with cerebral palsy: the impact on muscle morphology and strength

2012 ◽  
Vol 35 (7) ◽  
pp. 596-605 ◽  
Author(s):  
Sîan A. Williams ◽  
Catherine Elliott ◽  
Jane Valentine ◽  
Anna Gubbay ◽  
Peter Shipman ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Strength Training ◽  
Botulinum Neurotoxin ◽  
Muscle Morphology ◽  
Children With Cerebral Palsy ◽  
The Impact

scholarly journals Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy

2018 ◽  
Vol 60 (11) ◽  
pp. 1172-1177 ◽  
Author(s):  
Simon P Paget ◽  
Caitlyn M Swinney ◽  
Karen L O Burton ◽  
Karen Bau ◽  
Stephen J O'Flaherty
Keyword(s):  
Cerebral Palsy ◽  
Adverse Events ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Children With Cerebral Palsy

scholarly journals Joint and Muscle Assessments of the Separate Effects of Botulinum NeuroToxin-A and Lower-Leg Casting in Children With Cerebral Palsy

2020 ◽  
Vol 11 ◽  
Author(s):  
Nicky Peeters ◽  
Anja Van Campenhout ◽  
Britta Hanssen ◽  
Francesco Cenni ◽  
Simon-Henri Schless ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Botulinum Neurotoxin ◽  
Lower Leg ◽  
Botulinum Neurotoxin A ◽  
Children With Cerebral Palsy
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