In VivoPrecipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

2016 ◽  
Vol 13 (10) ◽  
pp. 3417-3426 ◽  
Author(s):  
P. J. Sassene ◽  
M. H. Michaelsen ◽  
M. D. Mosgaard ◽  
M. K. Jensen ◽  
E. Van Den Broek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

scholarly journals Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1968
Author(s):  
Mina Zare ◽  
Karolina Dziemidowicz ◽  
Gareth R. Williams ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Strong Electric Field ◽  
Solid Dispersions ◽  
Electrospun Nanofibers ◽  
Amorphous Solid ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Biological And Medical Applications

Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

scholarly journals Spiropyran-Based Drug Delivery Systems

2021 ◽  
Vol 9 ◽  
Author(s):  
Andrew Fagan ◽  
Michał Bartkowski ◽  
Silvia Giordani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Molecular Switches ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Recent Interest ◽  
Traditional Drug ◽  
Poorly Soluble

Nanocarriers are rapidly growing in popularity in the field of drug delivery. The ability of nanocarriers to encapsulate and distribute poorly soluble drugs while minimising their undesired effects is significantly advantageous over traditional drug delivery. Nanocarriers can also be decorated with imaging moieties and targeting agents, further incrementing their functionality. Of recent interest as potential nanocarriers are spiropyrans; a family of photochromic molecular switches. Due to their multi-responsiveness to endo- and exogenous stimuli, and their intrinsic biocompatibility, they have been utilised in various drug delivery systems (DDSs) to date. In this review, we provide an overview of the developments in spiropyran-based DDSs. The benefits and drawbacks of utilising spiropyrans in drug delivery are assessed and an outline of spiropyran-based drug delivery systems is presented.

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