scholarly journals Hierarchical Micro-Nano Surface Topography Promotes Long-Term Maintenance of Undifferentiated Mouse Embryonic Stem Cells

Nano Letters ◽  
2015 ◽  
Vol 15 (10) ◽  
pp. 7146-7154 ◽  
Author(s):  
Mona Jaggy ◽  
Ping Zhang ◽  
Alexandra M. Greiner ◽  
Tatjana J. Autenrieth ◽  
Victoria Nedashkivska ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Surface Topography ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Term Maintenance

Immobilization and long-term culturing of mouse embryonic stem cells in collagen-chitosan gel matrix

2006 ◽  
Vol 142 (1) ◽  
pp. 119-122 ◽  
Author(s):  
I. I. Selezneva ◽  
I. V. Savintseva ◽  
E. F. Vikhlyantseva ◽  
G. A. Davydova ◽  
B. K. Gavrilyuk
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Chitosan Gel

scholarly journals Assessment of Stem Cell Markers During Long-Term Culture of Mouse Embryonic Stem Cells

2004 ◽  
Vol 44 (1/2) ◽  
pp. 77-91 ◽  
Author(s):  
A. Berrill ◽  
H.L. Tan ◽  
S.C. Wuang ◽  
W.J. Fong ◽  
Andre B.H. Choo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Long Term Culture

scholarly journals Inhibition of β-catenin–TCF1 interaction delays differentiation of mouse embryonic stem cells

2015 ◽  
Vol 211 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Sujash S. Chatterjee ◽  
Abil Saj ◽  
Tenzin Gocha ◽  
Matthew Murphy ◽  
Foster C. Gonsalves ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Protein Interactions ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Protein Protein Interactions ◽  
Nanog Expression ◽  
Context Specific

The ability of mouse embryonic stem cells (mESCs) to self-renew or differentiate into various cell lineages is regulated by signaling pathways and a core pluripotency transcriptional network (PTN) comprising Nanog, Oct4, and Sox2. The Wnt/β-catenin pathway promotes pluripotency by alleviating T cell factor TCF3-mediated repression of the PTN. However, it has remained unclear how β-catenin’s function as a transcriptional activator with TCF1 influences mESC fate. Here, we show that TCF1-mediated transcription is up-regulated in differentiating mESCs and that chemical inhibition of β-catenin/TCF1 interaction improves long-term self-renewal and enhances functional pluripotency. Genetic loss of TCF1 inhibited differentiation by delaying exit from pluripotency and conferred a transcriptional profile strikingly reminiscent of self-renewing mESCs with high Nanog expression. Together, our data suggest that β-catenin’s function in regulating mESCs is highly context specific and that its interaction with TCF1 promotes differentiation, further highlighting the need for understanding how its individual protein–protein interactions drive stem cell fate.

scholarly journals Fucoidan Promotes Early Step of Cardiac Differentiation from Human Embryonic Stem Cells and Long-Term Maintenance of Beating Areas

2014 ◽  
Vol 20 (7-8) ◽  
pp. 1285-1294 ◽  
Author(s):  
Sofiane Hamidi ◽  
Didier Letourneur ◽  
Rachida Aid-Launais ◽  
Antonio Di Stefano ◽  
William Vainchenker ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cardiac Differentiation ◽  
Early Step ◽  
Term Maintenance

Defining Long-Term Maintenance Conditions of Human Embryonic Stem Cells With Arrayed Cellular Microenvironment Technology

2009 ◽  
Vol 18 (8) ◽  
pp. 1141-1154 ◽  
Author(s):  
David A. Brafman ◽  
Kevan D. Shah ◽  
Thomas Fellner ◽  
Shu Chien ◽  
Karl Willert
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cellular Microenvironment ◽  
Term Maintenance

scholarly journals An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Hideaki Tsutsui ◽  
Bahram Valamehr ◽  
Antreas Hindoyan ◽  
Rong Qiao ◽  
Xianting Ding ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Small Molecule ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Term Maintenance

Long-term culture of keratinocyte-like cells derived from mouse embryonic stem cells

2008 ◽  
Vol 44 (7) ◽  
pp. 193-203 ◽  
Author(s):  
Hai-Jun Huang ◽  
Qi-Shuang Gao ◽  
Bi-Fei Tao ◽  
Si-Wen Jiang
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Long Term Culture
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