Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol

2021 ◽  
Author(s):  
Zhongqing Wang ◽  
Zihong Zhou ◽  
Jingping Kou ◽  
Shuming Wu ◽  
Yongbo Xu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Starting Material ◽  
Efficient Synthesis

Efficient synthesis of ethylene glycol from cellulose over Ni–WO3/SBA-15 catalysts

2014 ◽  
Vol 381 ◽  
pp. 46-53 ◽  
Author(s):  
Yueling Cao ◽  
Junwei Wang ◽  
Maoqing Kang ◽  
Yulei Zhu
Keyword(s):  
Ethylene Glycol ◽  
Efficient Synthesis

Three-Component Synthesis of 4-Arylidene-3-alkylisoxazol-5(4H)-ones in the presence of potassium 2,5-dioxoimidazolidin-1-ide

2021 ◽  
Vol 25 ◽  
Author(s):  
Neda Reihani ◽  
Hamzeh Kiyani
Keyword(s):  
Ethylene Glycol ◽  
Ethyl Acetoacetate ◽  
Reaction Medium ◽  
Hydroxylamine Hydrochloride ◽  
Aromatic Aldehydes ◽  
Catalyst Loading ◽  
Efficient Synthesis ◽  
Current Process ◽  
High Yields ◽  
Low Catalyst Loading

: An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes with hydroxylamine hydrochloride and β-ketoesters. The potassium 2,5-dioxoimidazolidin-1-ide has been introduced as the new organocatalyst to facilitate of this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used for the synthesize of the number of substituted isoxazole-5(4H)-ones in good to high yields in ethylene glycol as a green reaction medium at 80 ºC. The low catalyst loading is also a main advantage over the some reported catalysts.

scholarly journals Correction: Role of enhanced solubility in esterification of 2,5-furandicarboxylic acid with ethylene glycol at reduced temperatures: energy efficient synthesis of poly(ethylene 2,5-furandicarboxylate)

2019 ◽  
Vol 4 (5) ◽  
pp. 954-954
Author(s):  
Anup S. Joshi ◽  
Niloofar Alipourasiabi ◽  
Yong-Wah Kim ◽  
Maria R. Coleman ◽  
Joseph G. Lawrence
Keyword(s):  
Ethylene Glycol ◽  
Energy Efficient ◽  
Efficient Synthesis ◽  
Enhanced Solubility ◽  
Furandicarboxylic Acid ◽  
Poly Ethylene

Correction for ‘Role of enhanced solubility in esterification of 2,5-furandicarboxylic acid with ethylene glycol at reduced temperatures: energy efficient synthesis of poly(ethylene 2,5-furandicarboxylate)’ by Anup S. Joshi et al., React. Chem. Eng., 2018, 3, 447–453.

Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

2015 ◽  
Vol 21 (4) ◽  
pp. 203-205
Author(s):  
Jianyu Guo ◽  
Yan Lu ◽  
Jin Wang
Keyword(s):  
Environmentally Friendly ◽  
Starting Material ◽  
Efficient Synthesis

Abstract5-Methyl-3-(bromomethyl)pyridine is the key intermediate in the synthesis of rupatadine. In this article, a new preparation of 5-methyl-3-(bromomethyl)pyridine hydrobromide is reported, which used 5-methylnicotinic acid as the starting material, with a 65.9% overall yield. This method has the merits of being simple, efficient and environmentally friendly.

A new and efficient synthesis of trifluoroalkyl aldehydes or ketones from the same starting material

1992 ◽  
Vol 33 (23) ◽  
pp. 3311-3314 ◽  
Author(s):  
André J. Laurent ◽  
Stanislaw Leniak
Keyword(s):  
Starting Material ◽  
Efficient Synthesis

A concise asymmetric synthesis of (−)-trans-aerangis lactone

2018 ◽  
Vol 96 (12) ◽  
pp. 1061-1063 ◽  
Author(s):  
Rachana Pandey ◽  
Ranjana Prakash
Keyword(s):  
Ethylene Glycol ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Aldol Reaction ◽  
Starting Material ◽  
Asymmetric Total Synthesis

A concise stereoselective approach to functionalized δ-lactone skeleton from monosilylated ethylene glycol as a starting material and its application to the asymmetric total synthesis of (−)-trans-aerangis lactone have been demonstrated. The synthesis utilizes the organocatalyzed MacMillan’s cross aldol reaction as a key step.

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