Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

2015 ◽  
Vol 21 (4) ◽  
pp. 203-205
Author(s):  
Jianyu Guo ◽  
Yan Lu ◽  
Jin Wang
Keyword(s):  
Environmentally Friendly ◽  
Starting Material ◽  
Efficient Synthesis

Abstract5-Methyl-3-(bromomethyl)pyridine is the key intermediate in the synthesis of rupatadine. In this article, a new preparation of 5-methyl-3-(bromomethyl)pyridine hydrobromide is reported, which used 5-methylnicotinic acid as the starting material, with a 65.9% overall yield. This method has the merits of being simple, efficient and environmentally friendly.

Efficient synthesis of glycosylamines in solventless conditions promoted by mechanical milling

RSC Advances ◽  
2014 ◽  
Vol 4 (68) ◽  
pp. 36350-36356 ◽  
Author(s):  
Cédric Epoune Lingome ◽  
Gwladys Pourceau ◽  
Virginie Gobert-Deveaux ◽  
Anne Wadouachi
Keyword(s):  
Mechanical Milling ◽  
Environmentally Friendly ◽  
Efficient Synthesis ◽  
Environmentally Friendly Approach

A mecanosynthesis of glycosylamines under solventless conditions was established. This environmentally friendly approach optimized with l-rhamnose, was investigated using a variety of amines and other carbohydrates.

Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol

2021 ◽  
Author(s):  
Zhongqing Wang ◽  
Zihong Zhou ◽  
Jingping Kou ◽  
Shuming Wu ◽  
Yongbo Xu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Starting Material ◽  
Efficient Synthesis

Efficient synthesis of esters through oxone-catalyzed dehydrogenation of carboxylic acids and alcohols

2018 ◽  
Vol 16 (48) ◽  
pp. 9472-9476 ◽  
Author(s):  
Fei Hou ◽  
Xi-Cun Wang ◽  
Zheng-Jun Quan
Keyword(s):  
Carboxylic Acids ◽  
Environmentally Friendly ◽  
Attractive Alternative ◽  
Efficient Synthesis

An environmentally friendly oxone (20 mol%) catalyzed esterification of carboxylic acids with alcohols has been developed, providing an attractive alternative to the construction of valuable carbonyl esters.

A new and efficient synthesis of trifluoroalkyl aldehydes or ketones from the same starting material

1992 ◽  
Vol 33 (23) ◽  
pp. 3311-3314 ◽  
Author(s):  
André J. Laurent ◽  
Stanislaw Leniak
Keyword(s):  
Starting Material ◽  
Efficient Synthesis

An Environmentally Friendly, Scalable and Highly Efficient Synthesis of (S,S)-Ethambutol, a First Line Drug against Tuberculosis

2015 ◽  
Vol 12 (7) ◽  
pp. 478-481 ◽  
Author(s):  
Raoni S.B. Goncalves ◽  
Emerson T. da Silva ◽  
Marcus Vinicius N. de Souza
Keyword(s):  
Environmentally Friendly ◽  
Efficient Synthesis ◽  
First Line ◽  
Highly Efficient ◽  
Line Drug

scholarly journals Efficient synthesis of some new antiproliferative N-fused indoles and isoquinolines via 1,3-dipolar cycloaddition reaction in an ionic liquid

2015 ◽  
Vol 39 (4) ◽  
pp. 2657-2668 ◽  
Author(s):  
Tushar R. Sutariya ◽  
Balvantsingh M. Labana ◽  
Narsidas J. Parmar ◽  
Rajni Kant ◽  
Vivek K. Gupta ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Cycloaddition Reaction ◽  
Reaction Medium ◽  
Environmentally Friendly ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis ◽  
Triethylammonium Acetate

Triethylammonium acetate (TEAA) as a new, recyclable and environmentally friendly reaction medium for the intramolecular[3+2] cycloaddition reaction.

scholarly journals Novel and Environmentally Friendly Synthesis of Pimavanserin (5-HT2A Receptor)

2019 ◽  
Vol 31 (3) ◽  
pp. 723-726 ◽  
Author(s):  
Rajesh Kumar Rapolu ◽  
V.V.N.K.V. Prasada Raju ◽  
Murthy Chavali ◽  
Naveen Mulakayala
Keyword(s):  
Environmentally Friendly ◽  
Starting Material ◽  
Water As Solvent

Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.

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