An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure–Activity Relationship (SAR) Study at C2 Position

2015 ◽  
Vol 17 (17) ◽  
pp. 4240-4243 ◽  
Author(s):  
Yongsheng Zheng ◽  
Jacob Cleaveland ◽  
David Richardson ◽  
Yu Yuan
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Sar Study

scholarly journals PRELIMINARY STRUCTURE–ACTIVITY RELATIONSHIP STUDY OF HEPTAMETHINE INDOCYANINE DYES FOR TUMOR-TARGETED IMAGING

2013 ◽  
Vol 06 (01) ◽  
pp. 1350003 ◽  
Author(s):  
QINYUAN GUO ◽  
SHENGLIN LUO ◽  
QINGRONG QI ◽  
CHUNMENG SHI
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Targeted Imaging ◽  
Structure Activity ◽  
Relationship Study ◽  
Tumor Accumulation ◽  
Sar Study

Our research has identified a couple of near-infrared (NIR) heptamethine indocyanine dyes exhibiting preferential tumor accumulation property for in vivo imaging. On the basis of our foregoing work, we describe here a preliminary structure–activity relationship (SAR) study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.

(7S)-Kaitocephalin as a potent NMDA receptor selective ligand

2016 ◽  
Vol 14 (4) ◽  
pp. 1206-1210 ◽  
Author(s):  
Yoko Yasuno ◽  
Makoto Hamada ◽  
Masanori Kawasaki ◽  
Keiko Shimamoto ◽  
Yasushi Shigeri ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligand ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Selective Ligand ◽  
Sar Study

A structure–activity relationship (SAR) study of kaitocephalin, known to be a potent naturally occurring NMDA receptor ligand, was performed.

scholarly journals OXIMES AS INHIBITORS OF ACETYLHOLINESTERASE - A STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY

2011 ◽  
Vol 80 (4) ◽  
pp. 178-186 ◽  
Author(s):  
Vendula Šepsová ◽  
Jana Žďárová Karasová ◽  
Filip Zemek ◽  
Brian J. Bennion ◽  
Kamil Kuča
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Sar Study

Synthesis of low-molecular weight fucoidan derivatives and their binding abilities to SARS-CoV-2 spike proteins

2021 ◽  
Author(s):  
Tatsuki Koike ◽  
Aoi Sugimoto ◽  
Shuhei Kosono ◽  
Sumika Komaba ◽  
Yuko Kanno ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Low Molecular Weight ◽  
Structure Activity ◽  
Sugar Chains ◽  
Sar Study ◽  
Spike Proteins

Fucoidan derivatives 10-13, whose basic sugar chains are composed of repeating α(1,4)-linked L-fucopyranosyl residues with different sulfation patterns, were designed and systematically synthesized. A structure-activity relationship (SAR) study examined competitive...

A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 2012-2022 ◽  
Author(s):  
Jaya P. Shrestha ◽  
Yagya Prasad Subedi ◽  
Liaohai Chen ◽  
Cheng-Wei Tom Chang
Keyword(s):  
Cancer Cells ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
New Class ◽  
Structure Activity ◽  
Sar Study

Previously, we reported the synthesis and structure–activity relationship (SAR) study of a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-3-ium salts, which had very potent anti-proliferative activities (low μM to nM GI50) against a broad range of cancer cells.

Heliannanes - a Structure-Activity Relationship (SAR) Study

Allelopathy ◽  
2003 ◽  
pp. 103-124
Author(s):  
J Galindo ◽  
J Molinillo ◽  
F Macías ◽  
D Chinchilla
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Sar Study
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