Protein-Mimicking Nanoparticles for a Cellular Regulation of Homeostasis

2021 ◽  
Author(s):  
Xiaoyuan Ji ◽  
Yanfeng Zhou ◽  
Qian Li ◽  
Haiyun Song ◽  
Chunhai Fan
Keyword(s):  
Cellular Regulation

Centrosome Structure And Function Is Altered By Experimental Manipulations With Formamide: Implications For Abnormal Cell Divisions During Cancer

1999 ◽  
Vol 5 (S2) ◽  
pp. 1286-1287
Author(s):  
Heide Schatten ◽  
Christopher N. Hueser ◽  
Amitabha Chakrabarti
Keyword(s):  
Cell Cycle ◽  
Genomic Stability ◽  
Cellular Regulation ◽  
Mitotic Apparatus ◽  
Abnormal Cell ◽  
Chemical Agents ◽  
Abnormal Mitosis ◽  
And Function ◽  
Normal Mitosis ◽  
Abnormal Cell Proliferation

The formation of abnormal mitosis associated with cancer has been intriguing for many decades. While microtubules had been the focus of previous studies, recent research has focused on centrosomes, microtubule organizing centers which organize the mitotic apparatus during cell division. During normal mitosis centrosomes form two poles but in cancer, centrosomes can form three, four, or more poles, and organize tripolar, quadripolar, and multipolar mitoses, respectively. This has severe consequences for genomic stability because chromosomes are separated unequally to three, four, or more poles. This can result in aneuploidy and gene amplifications with multiple defects in cellular regulation. It can result in malignancy that is accompanied by cell cycle imbalances and abnormal cell proliferation. While radiation and chemical agents are known to damage DNA and can lead to cell cycle abnormalities, the damage of centrosome structure leading to abnormal mitosis deserves also consideration.

Abnormal cellular regulation of lipolysis and phosphorylation in Reye's syndrome

1982 ◽  
Vol 27 (2) ◽  
pp. 180-194 ◽  
Author(s):  
Ellen S. Kang ◽  
Ronald E. Gates ◽  
Earle L. Wrenn
Keyword(s):  
Reye's Syndrome ◽  
Cellular Regulation

Oxidation of Methionine in Proteins: Roles in Antioxidant Defense and Cellular Regulation

IUBMB Life ◽  
2000 ◽  
Vol 50 (4) ◽  
pp. 301-307 ◽  
Author(s):  
Rodney L. Levine ◽  
Jackob Moskovitz ◽  
Earl R. Stadtman
Keyword(s):  
Antioxidant Defense ◽  
Cellular Regulation ◽  
Oxidation Of Methionine

Cellular Regulation of Sodium-Calcium Exchange

2006 ◽  
Vol 976 (1) ◽  
pp. 214-223 ◽  
Author(s):  
MADALINA CONDRESCU ◽  
KWABENA OPUNI ◽  
BASIL M. HANTASH ◽  
JOHN P. REEVES
Keyword(s):  
Cellular Regulation ◽  
Sodium Calcium ◽  
Calcium Exchange ◽  
Sodium Calcium Exchange

Casein kinase 2: An ‘eminence grise’ in cellular regulation?

1990 ◽  
Vol 1054 (3) ◽  
pp. 267-284 ◽  
Author(s):  
Lorenzo A. Pinna
Keyword(s):  
Casein Kinase ◽  
Casein Kinase 2 ◽  
Cellular Regulation

scholarly journals The protein phosphatases involved in cellular regulation. Glycolysis, gluconeogenesis and aromatic amino acid breakdown in rat liver

1984 ◽  
Vol 145 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Steven PELECH ◽  
Philip COHEN ◽  
Michael J. FISHER ◽  
Christopher I. POGSON ◽  
M. Raafat EL-MAGHRABI ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Liver ◽  
Aromatic Amino Acid ◽  
Protein Phosphatases ◽  
Cellular Regulation

scholarly journals Novel Roles of SH2 and SH3 Domains in Lipid Binding

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1191
Author(s):  
Szabolcs Sipeki ◽  
Kitti Koprivanacz ◽  
Tamás Takács ◽  
Anita Kurilla ◽  
Loretta László ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Specific Protein ◽  
Lipid Binding ◽  
Sh2 Domain ◽  
Essential Property ◽  
Cellular Regulation ◽  
Sh3 Domains ◽  
Protein Partners ◽  
Interaction Domains ◽  
Central Paradigm

Signal transduction, the ability of cells to perceive information from the surroundings and alter behavior in response, is an essential property of life. Studies on tyrosine kinase action fundamentally changed our concept of cellular regulation. The induced assembly of subcellular hubs via the recognition of local protein or lipid modifications by modular protein interactions is now a central paradigm in signaling. Such molecular interactions are mediated by specific protein interaction domains. The first such domain identified was the SH2 domain, which was postulated to be a reader capable of finding and binding protein partners displaying phosphorylated tyrosine side chains. The SH3 domain was found to be involved in the formation of stable protein sub-complexes by constitutively attaching to proline-rich surfaces on its binding partners. The SH2 and SH3 domains have thus served as the prototypes for a diverse collection of interaction domains that recognize not only proteins but also lipids, nucleic acids, and small molecules. It has also been found that particular SH2 and SH3 domains themselves might also bind to and rely on lipids to modulate complex assembly. Some lipid-binding properties of SH2 and SH3 domains are reviewed here.

Sign in / Sign up

Export Citation Format

Share Document