Culturing Belief

What kind of being are we? This of course is one of the oldest questions in philosophy. In earlier eras, answers were often non-naturalistic (we are animals with souls, for instance). Today, one of the oldest answers is also one of the most popular: with Aristotle, we often think we are distinguished from other animals by our rationality. This chapter suggests that another answer is at least as defensible: we are epistemically social animals. In making the case for this answer, it provides some of the background for the account of belief formation developed in the book. It highlights evidence from cultural evolution for our epistemic dependence on one another. Cultural evolution shows how human flourishing is due to cultural knowledge that escapes the grasp of individuals and that is the product of evolutionary processes. The chapter then turns to our central paradigm of a successful epistemic enterprise: modern science. It argues that science, too, owes its success to the way in which cognition is distributed across agents, groups, and even artifacts.

Die Entwicklung des „Steuerstaates“: Ursprung, Aufstieg und Ende eines finanzwirtschaftlichen Fortschrittsparadigmas

For decades, the Schumpeterian tax state was considered the central paradigm of Fiscal Sociology. However, it increasingly fails to meet many of the conceptual challenges of contemporary public finance. To demonstrate this, the paper undertakes a double re-contextualization of the discourse on public finance. Its development is traced back to evolutionary thinking, which Joseph Schumpeter updated around 1918. However, and following the rise of democratic capitalism after 1945, thinking about the tax state became intertwined with economic control. Its socio-political specifics were marginalized. Since the Great Recession of 2008/2009 and widening fiscal crises in advanced capitalist economies, this discursive narrowing has again become the subject of political and economic controversies.

Embracing Metagenomic Complexity with a Genome-Free Approach

A central paradigm in microbiome data analysis, which we term the genome-centric paradigm, is that a linear (nonbranching) DNA sequence is the ideal representation of a microbial genome. This representation is natural, as microbes indeed have nonbranching genomes.

Perturbation of kinetochore function using GFP-binding protein (GBP) in fission yeast

Using genetic mutations to study protein functions in vivo is a central paradigm of modern biology. Single-domain camelid antibodies generated against GFP have been engineered as nanobodies or GFP-binding proteins (GBPs) that can bind GFP as well as some GFP variants with high affinity and selectivity. In this study, we have used GBP-mCherry fusion protein as a tool to perturb the natural functions of a few kinetochore proteins in the fission yeast Schizosaccharomyces pombe. We found that cells simultaneously expressing GBP-mCherry and the GFP-tagged inner kinetochore protein Cnp1 are sensitive to high temperature and microtubule drug thiabendazole (TBZ). In addition, kinetochore-targeted GBP-mCherry by a few major kinetochore proteins with GFP tags causes defects in faithful chromosome segregation. Thus, this setting compromises the functions of kinetochores and renders cells to behave like conditional mutants. Our study highlights the potential of using GBP as a general tool to perturb the function of some GFP-tagged proteins in vivo with the objective of understanding their functional relevance to certain physiological processes, not only in yeasts, but also potentially in other model systems.

Complexity-stability relationship in empirical microbial ecosystems

May's stability theory, which holds that large ecosystems can be stable up to a critical level of complexity, a product of the number of resident species and the intensity of their interactions, has been a central paradigm in theoretical ecology. So far, however, empirically demonstrating this theory in real ecological systems has been a long-standing challenge, with inconsistent results. Especially, it is unknown whether this theory is pertinent in the rich and complex communities of natural microbiomes, mainly due to the challenge of reliably reconstructing such large ecological interaction networks. Here, we introduce a novel computational framework for estimating an ecosystem's complexity without relying on a priori knowledge of its underlying interaction network. By applying this method to human-associated microbial communities from different body sites and sponge-associated microbial communities from different geographical locations, we found that in both cases the communities display a pronounced trade-off between the number of species and their effective connectance. These results suggest that natural microbiomes are shaped by stability constraints, which limit their complexity.

Novel Roles of SH2 and SH3 Domains in Lipid Binding

Signal transduction, the ability of cells to perceive information from the surroundings and alter behavior in response, is an essential property of life. Studies on tyrosine kinase action fundamentally changed our concept of cellular regulation. The induced assembly of subcellular hubs via the recognition of local protein or lipid modifications by modular protein interactions is now a central paradigm in signaling. Such molecular interactions are mediated by specific protein interaction domains. The first such domain identified was the SH2 domain, which was postulated to be a reader capable of finding and binding protein partners displaying phosphorylated tyrosine side chains. The SH3 domain was found to be involved in the formation of stable protein sub-complexes by constitutively attaching to proline-rich surfaces on its binding partners. The SH2 and SH3 domains have thus served as the prototypes for a diverse collection of interaction domains that recognize not only proteins but also lipids, nucleic acids, and small molecules. It has also been found that particular SH2 and SH3 domains themselves might also bind to and rely on lipids to modulate complex assembly. Some lipid-binding properties of SH2 and SH3 domains are reviewed here.

Stem trait spectra underpin multiple functions of temperate gymnosperm and angiosperm tree species

A central paradigm in comparative ecology is that species sort out along a global economic strategy spectrum, ranging from slow to fast growth. Many studies evaluated plant strategy spectra for leaf traits, b u t few studies evaluated stem strategy spectra using a comprehensive set of anatomical, chemical and morphological traits, addressing key stem functions of different stem compartments (inner wood, outer wood and bark). This study evaluates how stem traits vary in the wood and bark of temperate tree species, and whether a slow-fast growth strategy spectrum exists and what traits make up this plant strategy spectrum. For 14 temperate gymnosperm and angiosperm species, 20 traits belonging to six key stem functions were measured for three stem compartments. Both across and within gymnosperms and angiosperms, a slow-fast stem strategy spectrum is found. Gymnosperms have slow traits and showed converging stem strategies because of their uniform tracheids. Angiosperms have fast traits and showed diverging stem strategies because of a wider array of tissues (vessels, parenchyma and fibers) and vessel size and arrangements (ring-porous versus diffuse porous). Gymnosperms showed a main trade-off between hydraulic efficiency and safety, and angiosperms showed a main trade-off between ‘slow’ diffuse porous species and ‘fast’ ring porous species. The slow traits of gymnosperms allow for a high hydraulic safety, an evergreen leaf habit and steady but slow growth makes them successful in unproductive habitats whereas the fast traits of angiosperms allow for high conductivity, a deciduous leaf habit and fast growth which makes them successful in productive habitats.

The primary dipole of flipper probes

The need of the primary dipole of flipper mechanophores has often been claimed but never confirmed. Here, a complete sulfur switching cycle is realized to prove that the central paradigm of fluorescent membrane tension probes is correct.

Value-free paradise is lost. Economists could learn from artists

Despite the conclusions from the contemporary philosophy of science, many economists cherish the ideal of positive science. Therefore, value-free economics is still the central paradigm in economics. The first aim of the paper is to investigate economics’ axiomatic assumptions from an epistemological perspective. The critical analysis of the literature shows that the positive-normative dichotomy is exaggerated. Moreover, value-free economics is based on normative foundations that have a negative impact on individuals and society. The paper’s second aim is to show that economics’ normativity is not a problem because the discussion concerning values is possible and unavoidable. In this context, Weber and other methodologists are investigated. The conclusion of the paper is that science can thrive without strict methodological rules thanks to institutional mechanisms. Therefore, economists could learn from artists who accept the world without absolute rules. This perspective opens the possibility for methodological pluralism and normative approaches.

Introduction

This chapter provides an introduction to this volume on social networks. It argues that social network analysis is greater than a method or data, but serves as a central paradigm for understanding social life. The chapter offers evidence of the influence of social network analysis with a bibliometric analysis of research on social networks. This analysis underscores how pervasive network analysis has become and highlights key theoretical and methodological concerns. It also introduces the sections of the volume broadly structured around theory, methods, broad conceptualizations like culture and temporality, and disciplinary contributions. The chapter concludes by discussing several promising new directions in the field of social network analysis.