Dual activatable self-assembled nanotheranostics for bioimaging and photodynamic therapy

AbstractPhotodynamic therapy (PDT) employs the combination of non-toxic photosensitizers (PS) together with harmless visible light of the appropriate wavelength to produce reactive oxygen species that kill unwanted cells. Because many PS are hydrophobic molecules prone to aggregation, numerous drug delivery vehicles have been tested to solubilize these molecules, render them biocompatible and enhance the ease of administration after intravenous injection. The recent rise in nanotechnology has markedly expanded the range of these nanoparticulate delivery vehicles beyond the well-established liposomes and micelles. Self-assembled nanoparticles are formed by judicious choice of monomer building blocks that spontaneously form a well-oriented 3-dimensional structure that incorporates the PS when subjected to the appropriate conditions. This self-assembly process is governed by a subtle interplay of forces on the molecular level. This review will cover the state of the art in the preparation and use of self-assembled liposomal nanoparticles within the context of PDT.

Download Full-text

A self-assembled cyclodextrin nanocarrier for photoreactive squaraine

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.12.248 ◽

2016 ◽

Vol 12 ◽

pp. 2535-2542 ◽

Cited By ~ 8

Author(s):

Ulrike Kauscher ◽

Bart Jan Ravoo

Keyword(s):

Photodynamic Therapy ◽

Fluorescence Spectroscopy ◽

Absorption Spectroscopy ◽

Photochemical Activity ◽

Oxygen Species ◽

Significant Potential ◽

Self Assembled

Photoreactive squaraines produce cytotoxic oxygen species under irradiation and have significant potential for photodynamic therapy. Herein we report that squaraines can be immobilized on a self-assembled nanocarrier composed of amphiphilic cyclodextrins to enhance their photochemical activity. To this end, a squaraine was equipped with two adamantane moieties that act as anchors for the cyclodextrin vesicle surface. The supramolecular immobilization was monitored by using fluorescence spectroscopy and microscopy and the photochemistry of the squaraine was investigated by using absorption spectroscopy.

Download Full-text

A Self-Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy

Chemistry - A European Journal ◽

10.1002/chem.201600852 ◽

2016 ◽

Vol 22 (17) ◽

pp. 5996-6000 ◽

Cited By ~ 23

Author(s):

Michael G. Walker ◽

Paul J. Jarman ◽

Martin R. Gill ◽

Xiaohe Tian ◽

Haslina Ahmad ◽

...

Keyword(s):

Photodynamic Therapy ◽

Singlet Oxygen ◽

Self Assembled

Download Full-text

Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

Chemical Communications ◽

10.1039/c4cc00349g ◽

2014 ◽

Vol 50 (57) ◽

pp. 7649-7651 ◽

Cited By ~ 16

Author(s):

Manpreet Bhatti ◽

Timothy D. McHugh ◽

Lilia Milanesi ◽

Salvador Tomas

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Multifunctional Nanoparticles ◽

Multifunctional Drugs ◽

Self Assembled

Multifunctional nanoparticles that kill mycobacteria: nano-Trojan horses for photodynamic therapy and anti-TB drug delivery.

Download Full-text

Self-assembled supramolecular nanoparticles mediated by host–guest interactions for photodynamic therapy

RSC Advances ◽

10.1039/c3ra48064j ◽

2014 ◽

Vol 4 (21) ◽

pp. 10708-10717 ◽

Cited By ~ 9

Author(s):

Hong Yan ◽

Xiaoyong Pan ◽

Ming Hui Chua ◽

Xiaobai Wang ◽

Jing Song ◽

...

Keyword(s):

Photodynamic Therapy ◽

Therapeutic Agent ◽

Photo Oxidation ◽

Supramolecular Nanoparticles ◽

Self Assembled ◽

Low Cytotoxicity ◽

Oxidation Efficiency

Supramolecular nanoparticles formed by calixarene-substituted porphyrin and biviologen were reported, offering a type of photodynamic therapeutic agent with low cytotoxicity and high photo-oxidation efficiency.

Download Full-text