scholarly journals Atomistic Simulations of the Mechanisms of the Poorly Catalytic Mitochondrial Chaperone Trap1: Insights into the Effects of Structural Asymmetry on Reactivity

ACS Catalysis ◽  
2021 ◽  
pp. 8605-8620
Author(s):  
Stefano A. Serapian ◽  
Elisabetta Moroni ◽  
Mariarosaria Ferraro ◽  
Giorgio Colombo
Keyword(s):  
Atomistic Simulations ◽  
Structural Asymmetry

scholarly journals The mammalian plasma membrane is defined by transmembrane asymmetries in lipid unsaturation, leaflet packing, and protein shape

2019 ◽  
Author(s):  
JH Lorent ◽  
KR Levental ◽  
L Ganesan ◽  
G Rivera-Longsworth ◽  
E. Sezgin ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Fluorescent Probes ◽  
Plasma Membranes ◽  
Atomistic Simulations ◽  
Biophysical Properties ◽  
Fundamental Feature ◽  
Structural Asymmetry ◽  
Asymmetric Structures ◽  
Lipid Unsaturation ◽  
Protein Shape

SUMMARYA fundamental feature of cellular plasma membranes (PM) is asymmetric lipid distribution between the bilayer leaflets. However, neither the detailed, comprehensive compositions of individual PM leaflets, nor how these contribute to structural membrane asymmetries have been defined. We report the distinct lipidomes and biophysical properties of both monolayers in living mammalian PMs. Phospholipid unsaturation is dramatically asymmetric, with the cytoplasmic leaflet being ∼2-fold more unsaturated than the exoplasmic. Atomistic simulations and spectroscopy of leaflet-selective fluorescent probes reveal that the outer PM leaflet is more packed and less diffusive than the inner leaflet, with this biophysical asymmetry maintained in the endocytic system. The structural asymmetry of the PM is reflected in asymmetric structures of protein transmembrane domains (TMD). These structural asymmetries are conserved throughout Eukaryota, suggesting fundamental cellular design principles.

ATOMISTIC SIMULATIONS OF [100], [110] AND [111] SYMMETRIC TILT GRAIN BOUNDARIES IN Ni3Al

1990 ◽  
Vol 51 (C1) ◽  
pp. C1-227-C1-232
Author(s):  
D. T.L. LIN ◽  
D. CHEN
Keyword(s):  
Grain Boundaries ◽  
Atomistic Simulations ◽  
Symmetric Tilt

The Imitation Game: Structural Asymmetry in Multidistrict Litigation

2017 ◽  
Author(s):  
Jeff Lingwall ◽  
Isaac Ison ◽  
Chris Wray
Keyword(s):  
Imitation Game ◽  
Structural Asymmetry

Atomistic Simulations of Ultrashort Pulsed Laser Ablation of Polycrystalline Diamond

2013 ◽  
Vol 9 (6) ◽  
pp. 804-811 ◽  
Author(s):  
Z. Li ◽  
J. Wang ◽  
T. Sun
Keyword(s):  
Laser Ablation ◽  
Pulsed Laser ◽  
Polycrystalline Diamond ◽  
Pulsed Laser Ablation ◽  
Atomistic Simulations ◽  
Ultrashort Pulsed Laser

scholarly journals Atomistic simulations of the thermal conductivity of liquids

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Marcello Puligheddu ◽  
Giulia Galli
Keyword(s):  
Thermal Conductivity ◽  
Atomistic Simulations

Atomistic simulations to study crack tip behaviour in multi-elemental alloys

2021 ◽  
Vol 243 ◽  
pp. 107536
Author(s):  
Sandeep Kumar Singh ◽  
Avinash Parashar
Keyword(s):  
Crack Tip ◽  
Atomistic Simulations
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