Variable Metal Chelation Modes and Activation Sequence in Pd-Catalyzed B–H Poly-arylation of Carboranes

ACS Catalysis ◽  
2021 ◽  
pp. 14047-14057
Author(s):  
Hou-ji Cao ◽  
Meng Chen ◽  
Fangxiang Sun ◽  
Yue Zhao ◽  
Changsheng Lu ◽  
...  
Keyword(s):  
Metal Chelation ◽  
Activation Sequence

Drug Design of Inhibitors of Alzheimer’s Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of β-amino di-Carbonyl Derivatives

2019 ◽  
Vol 19 (8) ◽  
pp. 688-705
Author(s):  
Taibi Ben Hadda ◽  
Abdur Rauf ◽  
Hsaine Zgou ◽  
Fatma Sezer Senol ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibitors ◽  
Metal Accumulation ◽  
Microtiter Plate ◽  
Metal Chelation ◽  
Carbonyl Derivatives ◽  
Cholinesterase Inhibitory Activity ◽  
Inhibitory Potential

Background:Since deficit of acetylcholine has been evidenced in the Alzheimer’s disease (AD) patients, cholinesterase inhibitors are currently the most specified drug category for the remediation of AD.Method:In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in vitro against AChE and BChE using ELISA microtiter plate assays at 100 μg/mL. Since metal accumulation is related to AD, the compounds were also tested for their metal-chelation capacity.Results and Conclusion:All the investigated dicarbonyl compounds exerted none or lower than 30% inhibition against both cholinesterases, whereas compounds 2, 8 and 11 showed 37, 42, 41% of inhibition towards BChE, being the most active. The highest metal-chelation capacity was observed with compound 8 (53.58 ± 2.06%). POM and DFT analyses are in good harmonization with experimental data.

scholarly journals Fungal Melanins and Applications in Healthcare, Bioremediation and Industry

2021 ◽  
Vol 7 (6) ◽  
pp. 488
Author(s):  
Ellie Rose Mattoon ◽  
Radames J. B. Cordero ◽  
Arturo Casadevall
Keyword(s):  
Chemical Structure ◽  
Industrial Processes ◽  
Metal Chelation ◽  
Biological Functions ◽  
Societal Benefit ◽  
Potential Applications ◽  
Fungal Melanin ◽  
Human Use ◽  
Fungal Melanins ◽  
Isolated Species

Melanin is a complex multifunctional pigment found in all kingdoms of life, including fungi. The complex chemical structure of fungal melanins, yet to be fully elucidated, lends them multiple unique functions ranging from radioprotection and antioxidant activity to heavy metal chelation and organic compound absorption. Given their many biological functions, fungal melanins present many possibilities as natural compounds that could be exploited for human use. This review summarizes the current discourse and attempts to apply fungal melanin to enhance human health, remove pollutants from ecosystems, and streamline industrial processes. While the potential applications of fungal melanins are often discussed in the scientific community, they are successfully executed less often. Some of the challenges in the applications of fungal melanin to technology include the knowledge gap about their detailed structure, difficulties in isolating melanotic fungi, challenges in extracting melanin from isolated species, and the pathogenicity concerns that accompany working with live melanotic fungi. With proper acknowledgment of these challenges, fungal melanin holds great potential for societal benefit in the coming years.

scholarly journals Nanoparticle and other metal chelation therapeutics in Alzheimer disease

2005 ◽  
Vol 1741 (3) ◽  
pp. 246-252 ◽  
Author(s):  
Gang Liu ◽  
Matthew R. Garrett ◽  
Ping Men ◽  
Xiongwei Zhu ◽  
George Perry ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Metal Chelation

Editorial [Hot topic: Metal Chelation (Guest Editors: Paul V. Bernhardt & Des R. Richardson)]

2011 ◽  
Vol 11 (5) ◽  
pp. 482-482 ◽  
Author(s):  
Paul V. Bernhardt ◽  
Des R. Richardson
Keyword(s):  
Metal Chelation

Change in the Retrograde Atrial Activation Sequence Following Radiofrequency Modification of the Atrioventricular Node:

2003 ◽  
Vol 14 (5) ◽  
pp. 461-466 ◽  
Author(s):  
José Dizon ◽  
James Reiffel ◽  
John Kassotis ◽  
Ian Woollett ◽  
Hasan Garan
Keyword(s):  
Atrioventricular Node ◽  
Atrial Activation ◽  
Activation Sequence

scholarly journals Characterization of Metal Chelation with a Mutagenic Agent, 5-Bromouracil

1990 ◽  
Vol 63 (4) ◽  
pp. 1226-1229 ◽  
Author(s):  
Udai P. Singh ◽  
Ranjana Ghose ◽  
Animesh K. Ghose
Keyword(s):  
Metal Chelation ◽  
Mutagenic Agent

scholarly journals Identification of the site of origin of ventricular premature beats and its activation sequence by body surface isopotential map.

1981 ◽  
Vol 45 (10) ◽  
pp. 1182-1186 ◽  
Author(s):  
HIROSHI HAYASHI ◽  
TOMIHISA ISHIKAWA ◽  
HARUYOSHI UEMATSU
Keyword(s):  
Body Surface ◽  
Ventricular Premature Beats ◽  
Premature Beats ◽  
Activation Sequence

Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence

2005 ◽  
Vol 289 (6) ◽  
pp. H2724-H2732 ◽  
Author(s):  
Xin Zhang ◽  
Indiresha Ramachandra ◽  
Zhongming Liu ◽  
Basharat Muneer ◽  
Steven M. Pogwizd ◽  
...  
Keyword(s):  
Surface Potential ◽  
Body Surface ◽  
Cardiac Arrhythmias ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Electrocardiographic Imaging ◽  
Ventricular Activation ◽  
Body Surface Potential ◽  
Life Threatening ◽  
Activation Sequence

Imaging the myocardial activation sequence is critical for improved diagnosis and treatment of life-threatening cardiac arrhythmias. It is desirable to reveal the underlying cardiac electrical activity throughout the three-dimensional (3-D) myocardium (rather than just the endocardial or epicardial surface) from noninvasive body surface potential measurements. A new 3-D electrocardiographic imaging technique (3-DEIT) based on the boundary element method (BEM) and multiobjective nonlinear optimization has been applied to reconstruct the cardiac activation sequences from body surface potential maps. Ultrafast computerized tomography scanning was performed for subsequent construction of the torso and heart models. Experimental studies were then conducted, during left and right ventricular pacing, in which noninvasive assessment of ventricular activation sequence by means of 3-DEIT was performed simultaneously with 3-D intracardiac mapping (up to 200 intramural sites) using specially designed plunge-needle electrodes in closed-chest rabbits. Estimated activation sequences from 3-DEIT were in good agreement with those constructed from simultaneously recorded intracardiac electrograms in the same animals. Averaged over 100 paced beats (from a total of 10 pacing sites), total activation times were comparable (53.3 ± 8.1 vs. 49.8 ± 5.2 ms), the localization error of site of initiation of activation was 5.73 ± 1.77 mm, and the relative error between the estimated and measured activation sequences was 0.32 ± 0.06. The present experimental results demonstrate that the 3-D paced ventricular activation sequence can be reconstructed by using noninvasive multisite body surface electrocardiographic measurements and imaging of heart-torso geometry. This new 3-D electrocardiographic imaging modality has the potential to guide catheter-based ablative interventions for the treatment of life-threatening cardiac arrhythmias.

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