Metal-Catalyzed One-Pot On-DNA Syntheses of Diarylmethane and Thioether Derivatives

ACS Catalysis ◽  
2022 ◽  
pp. 1639-1649
Author(s):  
Fei Ma ◽  
Jie Li ◽  
Shuning Zhang ◽  
Yuang Gu ◽  
Tingting Tan ◽  
...  
Keyword(s):  
One Pot ◽  
Metal Catalyzed

Synthesis of Chlorinated Arenes and Hetarenes by One-Pot Cyclizations of 1,3-Bis-silyl Enol Ethers

Synlett ◽  
2019 ◽  
Vol 30 (06) ◽  
pp. 665-673 ◽  
Author(s):  
Peter Langer ◽  
Zahid Hassan
Keyword(s):  
Cost Effective ◽  
Coupling Reactions ◽  
One Pot ◽  
Enol Ethers ◽  
Silyl Enol Ethers ◽  
Cross Coupling Reactions ◽  
Silyl Enol Ether ◽  
Synthetic Routes ◽  
Metal Catalyzed ◽  
High Level

This account describes our recent findings and progress in synthesizing chlorinated arenes and hetarenes by one-pot cyclizations of 1,3-bis-silyl enol ether derivatives. These reactions allow for the preparation of highly functionalized products with a high level of regioselectivity. The synthetic routes are cost-effective avoiding additional functionalization steps. The products are difficult to be accessed by other methods. The chlorine atom is of relevance in medicinal and agriculture chemistry. In addition, it allows further functionalizations by transition-metal-catalyzed cross-coupling reactions.1 Introduction2 Cyclizations of 2-Chloro-1,3-bis(silyloxy)-1,3-butadienes2.1 3,5-Dihydroxychlorophthalates2.2 2,4-Dihydroxy-homochlorophthalates2.3 2-(Arylsulfonyl)chloropyridines2.4 1-Azaxanthones3 Cyclizations of 4-Chloro-1,3-bis(trimethylsilyloxy)-1,3-butadienes3.1 3-Chlorosalicylates3.2 Functionalized Chlorobiaryls3.3 3-Chloro-5-(2-chloroethyl)-salicylates3.4 2,4-Dihydroxychlorobenzophenones4 Cyclizations of 2-Chloro-3-(silyloxy)-2-en-1-ones4.1 Functionalized Chlorophenols4.2 Functionalized Chlorinated Biaryls and Chlorofluorenones4.3 Functionalized Chlorochromenones4.4 Functionalized 3-(Methylthio)chlorophenols4.5 Functionalized 3-Chloromethylphenols5 Conclusions6 List of Abbreviations

Real-time monitoring of a cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction

2020 ◽  
Vol 508 ◽  
pp. 119654
Author(s):  
Antônio E.M. Crotti ◽  
Daniel Previdi ◽  
Paulo M. Donate ◽  
J. Scott McIndoe
Keyword(s):  
Transition Metal ◽  
Real Time ◽  
Multicomponent Reaction ◽  
Real Time Monitoring ◽  
One Pot ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-dihydroquinazolin-4(1H )-one Derivatives via One-Pot Multicomponent Reactions

2019 ◽  
Vol 4 (1) ◽  
pp. 100-104 ◽  
Author(s):  
Saeed Bahadorikhalili ◽  
Golnaz Rahimzadeh ◽  
Ebrahim Kianmehr ◽  
Samira Ansari ◽  
Haleh Hamedifar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Multicomponent Reactions ◽  
One Pot ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals Real-Time Monitoring of a Cobalt-Mediated One-Pot Transition Metal Catalyzed Multicomponent Reaction

2020 ◽  
Author(s):  
Antonio Crotti ◽  
Daniel Previdi ◽  
Paulo Donate ◽  
J Scott McIndoe
Keyword(s):  
Transition Metal ◽  
Real Time ◽  
Multicomponent Reaction ◽  
Side Reaction ◽  
Ionization Mass ◽  
One Pot ◽  
Esi Ms ◽  
Transition Metal Catalyzed ◽  
Time Changes ◽  
Metal Catalyzed

In this paper, pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS) and FTIR spectroscopy was used to investigate the mechanism of a like-Barbier cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction (MCR). The use of charge-tagged aryl halides allowed for the detection of cobalt(II)-promoted hydrodehalogenation products. Although these products were also detected in the off-line ESI-MS monitoring, the ability of PSI-ESI-MS to track real-time changes in the reaction mixture composition proved cobalt(II) was responsible for the undesired transformation. The occurrence of cobalt(II)-promoted hydrodehalogenation as a side reaction in this MCR had not been considered in previous mechanistic proposals and represents an important mechanistic consideration.

ChemInform Abstract: SYNTHESIS OF PYRIMIDINES FROM β-DICARBONYL COMPOUNDS AND CYANOGEN: A METAL-CATALYZED ONE-POT PROCESS

1984 ◽  
Vol 15 (38) ◽  
Author(s):  
M. BASATO ◽  
B. CORAIN ◽  
A. MARCOMINI ◽  
G. VALLE ◽  
G. ZANOTTI
Keyword(s):  
One Pot ◽  
Dicarbonyl Compounds ◽  
Metal Catalyzed

A comparative study of metal-catalyzed three-component synthesis of α-aminophosphonates

2021 ◽  
pp. 221-234
Author(s):  
Marwa M. Abdeen ◽  
Mohamed A. Hamed ◽  
Abdel Aleem Hassan Abdel Aleem ◽  
Ibrahim F. Nassar ◽  
Ibrahim E.T. El-Sayed
Keyword(s):  
Carbonyl Compounds ◽  
Room Temperature ◽  
Lithium Perchlorate ◽  
Aprotic Solvents ◽  
Electronic Factor ◽  
One Pot ◽  
Catalyst Type ◽  
Metal Catalyzed ◽  
The One ◽  
Metal Triflates

Different metal catalysts have been tested for the one-pot transformation of carbonyl compounds, amines and phosphites to α-aminophosphonates. The influence of catalyst type, amount, solvent and the substrate electronic factor have been investigated. The results revealed that the carbonyl compounds could be smoothly converted into α-aminophosphonates at room temperature in good to excellent yields, with or without solvent in a reasonable reaction time. These results suggested that among others, lithium perchlorate and metal triflates were proven to be effective catalysts in 10 moles % catalysts. Polar aprotic solvents proved to be the best for the synthesis of α-aminophosphonates. The synthesized compounds' structure characterizations were elucidated by different spectroscopic tools and showed results consistent with the expected structures.

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