An acid–base bifunctional nano-catalyst was synthesized and applied as an efficient and recoverable catalyst in the one-pot deacetalization–Knoevenagel tandem reaction.
One-pot synthesis of (2-furanylmethylene)malononitrile, a Knoevenagel product of furfural with malononitrile, from xylose efficiently proceeded by combined use of acid Amberlyst-15 and acid-base Cr/hydrotalcites in 44% yield.