Scope of β-Secretase (BACE1)-Targeted Therapy in Alzheimer’s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition

2020 ◽  
Vol 11 (21) ◽  
pp. 3510-3522
Author(s):  
Sucharita Das ◽  
Swaha Sengupta ◽  
Sandipan Chakraborty
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Targeted Therapy ◽  
Bace1 Inhibition

Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease

2020 ◽  
Vol 30 (27) ◽  
pp. 1909999 ◽  
Author(s):  
Lulu Cai ◽  
Chuanyao Yang ◽  
Wenfeng Jia ◽  
Yuwei Liu ◽  
Rou Xie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Targeted Therapy

scholarly journals Disease Staging and Milestones

2007 ◽  
Vol 34 (S1) ◽  
pp. S62-S66 ◽  
Author(s):  
Kiran Rabheru
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Targeted Therapy ◽  
Caregiver Burden ◽  
Surrogate Markers ◽  
Global Function ◽  
Disease Staging

This new section to the guidelines was added due to the recognition that clinical milestones are useful indices of the progression of dementia in patients with Alzheimer's disease and could help in the development of stage-specific targeted therapy. This review specifically looks at clinical milestones that could be used in clinical trials, such as global function, function, behaviour, caregiver burden, and quality of life milestones. It also addresses the possible use of biological and surrogate markers for use as milestones - which may eventually replace clinical milestones. It concludes that current definitions of dementia must be broadened beyond cognition alone to include some of the domains listed.

scholarly journals Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept

Brain ◽  
2017 ◽  
Vol 141 (2) ◽  
pp. 596-612 ◽  
Author(s):  
Izumi Maezawa ◽  
Hai M Nguyen ◽  
Jacopo Di Lucente ◽  
David Paul Jenkins ◽  
Vikrant Singh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Targeted Therapy ◽  
Proof Of Concept
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