Amyloid-β Peptide Interactions with Amphiphilic Surfactants: Electrostatic and Hydrophobic Effects

2018 ◽  
Vol 9 (7) ◽  
pp. 1680-1692 ◽  
Author(s):  
Nicklas Österlund ◽  
Yashraj S. Kulkarni ◽  
Agata D. Misiaszek ◽  
Cecilia Wallin ◽  
Dennis M. Krüger ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Hydrophobic Effects ◽  
Peptide Interactions

ChemInform Abstract: Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

ChemInform ◽  
2013 ◽  
Vol 44 (47) ◽  
pp. no-no
Author(s):  
Sebastian Waermlaender ◽  
Ann Tiiman ◽  
Axel Abelein ◽  
Jinghui Luo ◽  
Jyri Jarvet ◽  
...  
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions ◽  
Biophysical Studies

NMR Investigations of Amyloid-β Peptide Interactions with Propofol at Clinically Relevant Concentrations with and without Aqueous Halothane Solution

2010 ◽  
Vol 21 (4) ◽  
pp. 1303-1309 ◽  
Author(s):  
Pravat K. Mandal ◽  
Neel Sarovar Bhavesh ◽  
Virender S. Chauhan ◽  
Vincenzo Fodale
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

ChemBioChem ◽  
2013 ◽  
Vol 14 (14) ◽  
pp. 1692-1704 ◽  
Author(s):  
Sebastian Wärmländer ◽  
Ann Tiiman ◽  
Axel Abelein ◽  
Jinghui Luo ◽  
Jyri Jarvet ◽  
...  
Keyword(s):  
Metal Ions ◽  
Small Molecules ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions ◽  
Biophysical Studies

scholarly journals Erratum to: Probing of Various Physiologically Relevant Metals–Amyloid-β Peptide Interactions with a Lipid Membrane-Immobilized Protein Nanopore

2014 ◽  
Vol 247 (6) ◽  
pp. 531-531
Author(s):  
Alina Asandei ◽  
Sorana Iftemi ◽  
Loredana Mereuta ◽  
Irina Schiopu ◽  
Tudor Luchian
Keyword(s):  
Lipid Membrane ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions

Probing of Various Physiologically Relevant Metals: Amyloid-β Peptide Interactions with a Lipid Membrane-Immobilized Protein Nanopore

2014 ◽  
Vol 247 (6) ◽  
pp. 523-530 ◽  
Author(s):  
Alina Asandei ◽  
Sorana Iftemi ◽  
Loredana Mereuta ◽  
Irina Schiopu ◽  
Tudor Luchian
Keyword(s):  
Lipid Membrane ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Interactions

Amyloid β-peptide and Alzheimer's disease

2014 ◽  
Vol 56 ◽  
pp. 99-110 ◽  
Author(s):  
David Allsop ◽  
Jennifer Mayes
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Senile Plaques ◽  
Strong Support ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Cascade Hypothesis ◽  
Sequence Of Events ◽  
Aβ Amyloid ◽  
Amyloid Cascade

One of the hallmarks of AD (Alzheimer's disease) is the formation of senile plaques in the brain, which contain fibrils composed of Aβ (amyloid β-peptide). According to the ‘amyloid cascade’ hypothesis, the aggregation of Aβ initiates a sequence of events leading to the formation of neurofibrillary tangles, neurodegeneration, and on to the main symptom of dementia. However, emphasis has now shifted away from fibrillar forms of Aβ and towards smaller and more soluble ‘oligomers’ as the main culprit in AD. The present chapter commences with a brief introduction to the disease and its current treatment, and then focuses on the formation of Aβ from the APP (amyloid precursor protein), the genetics of early-onset AD, which has provided strong support for the amyloid cascade hypothesis, and then on the development of new drugs aimed at reducing the load of cerebral Aβ, which is still the main hope for providing a more effective treatment for AD in the future.

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