Quartz Crystal Microbalance (QCM) is used for detecting microgram level mass changes in gas and liquid phase. Conventional QCM design comprises a circular electrode configuration with an evenly distributed mass loading area. However, their mass sensitivity distribution is found to be non-uniform due to the inherent energy trapping effect. In this paper, the recently developed QCM with a ring electrode and a ring-dot electrode configuration are evaluated. It is shown that this new configuration offers the ability to achieve a uniform mass sensitivity distribution, while attaining a comparable mass sensitivity for a reduced mass loading area. Finite Element Analysis is used to design and evaluate the conventional circular electrode QCM, and the proposed ring electrode and ring-dot electrode QCM configurations, where the mass loading area is reduced by 25% compared with the conventional sensor. Simulations are conducted to determine the sensor’s resonant frequency shifts for an added mass per unit area of 20 μg/mm2. The results indicate that newly designed ring and ring-dot electrode configurations operate at a higher resonant frequency. The observed frequency shift for the designed circular electrode, ring electrode, and ring-dot electrode configurations on a 333 μm thick quartz substrate are 85 kHz, 84 kHz, and 82 kHz, respectively. It is shown that the ring electrode and new ring-dot electrode configurations achieve a higher resonant frequency and offer a comparable sensing performance despite comprising of over 25% reduced mass loading area, in comparison to the conventional circular electrode configuration.