scholarly journals Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1

2020 ◽  
Vol 3 (4) ◽  
pp. 690-705 ◽  
Author(s):  
Fabian Bumbak ◽  
Trayder Thomas ◽  
Billy J. Noonan-Williams ◽  
Tasneem M. Vaid ◽  
Fei Yan ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Neurotensin Receptor ◽  
Neurotensin Receptor 1

scholarly journals Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK 1/2 and cell proliferation via Gαq‐mediated mechanism

2014 ◽  
Vol 18 (10) ◽  
pp. 2071-2081 ◽  
Author(s):  
Bo Bai ◽  
Xin Cai ◽  
Yunlu Jiang ◽  
Emmanouil Karteris ◽  
Jing Chen
Keyword(s):  
Cell Proliferation ◽  
Neurotensin Receptor ◽  
Apelin Receptor ◽  
Neurotensin Receptor 1

scholarly journals Neurotensin and neurotensin receptor 1 mRNA expression in song-control regions changes during development in male zebra finches

2018 ◽  
Vol 78 (7) ◽  
pp. 671-686
Author(s):  
Devin P. Merullo ◽  
Chinweike N. Asogwa ◽  
Miguel Sanchez-Valpuesta ◽  
Shin Hayase ◽  
Bikash R. Pattnaik ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Zebra Finches ◽  
Neurotensin Receptor ◽  
Song Control ◽  
Neurotensin Receptor 1 ◽  
Control Regions

scholarly journals Neurotensin receptor 1 deletion decreases methamphetamine self‐administration and the associated reduction in dopamine cell firing

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Sergio Dominguez‐Lopez ◽  
Ramaswamy Sharma ◽  
Michael J. Beckstead
Keyword(s):  
Self Administration ◽  
Neurotensin Receptor ◽  
Cell Firing ◽  
Neurotensin Receptor 1 ◽  
Dopamine Cell

Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use

2019 ◽  
Vol 46 (10) ◽  
pp. 2199-2207 ◽  
Author(s):  
Tingting He ◽  
Mengzhe Wang ◽  
Hui Wang ◽  
Hongpei Tan ◽  
Yongxiang Tang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Neurotensin Receptor ◽  
Potential Biomarker ◽  
Neurotensin Receptor 1

scholarly journals Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Julian Budzinski ◽  
Simone Maschauer ◽  
Hiroyuki Kobayashi ◽  
Pierre Couvineau ◽  
Hannah Vogt ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Interaction ◽  
Endosomal Trafficking ◽  
Receptor Ligands ◽  
Bivalent Ligands ◽  
Neurotensin Receptor ◽  
Neuropsychiatric Diseases ◽  
Dopamine D3 ◽  
Neurotensin Receptor 1 ◽  
G Protein Coupled

AbstractBivalent ligands are composed of two pharmacophores connected by a spacer of variable size. These ligands are able to simultaneously recognize two binding sites, for example in a G protein-coupled receptor heterodimer, resulting in enhanced binding affinity. Taking advantage of previously described heterobivalent dopamine-neurotensin receptor ligands, we demonstrate specific interactions between dopamine D3 (D3R) and neurotensin receptor 1 (NTSR1), two receptors with expression in overlapping brain areas that are associated with neuropsychiatric diseases and addiction. Bivalent ligand binding to D3R-NTSR1 dimers results in picomolar binding affinity and high selectivity compared to the binding to monomeric receptors. Specificity of the ligands for the D3R-NTSR1 receptor pair over D2R-NTSR1 dimers can be achieved by a careful choice of the linker length. Bivalent ligands enhance and stabilize the receptor-receptor interaction leading to NTSR1-controlled internalization of D3R into endosomes via recruitment of β-arrestin, highlighting a potential mechanism for dimer-specific receptor trafficking and signalling.

Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth

2019 ◽  
Vol 58 (12) ◽  
pp. 2230-2240
Author(s):  
Hiroto Tokumoto ◽  
Takao Setoguchi ◽  
Yoshinobu Saitoh ◽  
Hiromi Sasaki ◽  
Satoshi Nagano ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Neurotensin Receptor ◽  
Pleomorphic Sarcoma ◽  
Neurotensin Receptor 1

scholarly journals Identification of Residues Involved in Neurotensin Binding and Modeling of the Agonist Binding Site in Neurotensin Receptor 1

2000 ◽  
Vol 275 (1) ◽  
pp. 328-336 ◽  
Author(s):  
Séverine Barroso ◽  
Françoise Richard ◽  
Delphine Nicolas-Ethève ◽  
Jean-Louis Reversat ◽  
Jean-Marie Bernassau ◽  
...  
Keyword(s):  
Binding Site ◽  
Agonist Binding ◽  
Neurotensin Receptor ◽  
Neurotensin Receptor 1
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