scholarly journals (S)-5-(2′-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder

2020 ◽  
Vol 3 (3) ◽  
pp. 509-523
Author(s):  
Jessica L. Armstrong ◽  
Austen B. Casey ◽  
Tanishka S. Saraf ◽  
Munmun Mukherjee ◽  
Raymond G. Booth ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Fragile X Syndrome ◽  
Knockout Mouse ◽  
Serotonin Receptor ◽  
Fragile X ◽  
Autism Spectrum ◽  
Knockout Mouse Model ◽  
Receptor Modulator ◽  
Fmr1 Knockout Mouse

scholarly journals GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome

eNeuro ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. ENEURO.0380-16.2017 ◽  
Author(s):  
D. Sinclair ◽  
R. Featherstone ◽  
M. Naschek ◽  
J. Nam ◽  
A. Du ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Knockout Mouse ◽  
Fragile X ◽  
Neural Oscillations ◽  
Behavioral Deficits ◽  
Knockout Mouse Model ◽  
Fmr1 Knockout Mouse

scholarly journals Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome

2005 ◽  
Vol 4 (7) ◽  
pp. 420-430 ◽  
Author(s):  
C. M. Spencer ◽  
O. Alekseyenko ◽  
E. Serysheva ◽  
L. A. Yuva-Paylor ◽  
R. Paylor
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Knockout Mouse ◽  
Fragile X ◽  
Social Behaviors ◽  
Knockout Mouse Model ◽  
Fmr1 Knockout Mouse

Pet Imaging of mGluR5 in Fragile X Syndrome: A Longitudinal Study Using a FMR1 Knockout Mouse Model

2021 ◽  
Author(s):  
Sepideh Afshar ◽  
Sevda Lule ◽  
Gengyang Yuan ◽  
Xiying Qu ◽  
Chuzhi Pan ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Mouse Model ◽  
Fragile X Syndrome ◽  
Pet Imaging ◽  
Knockout Mouse ◽  
Fragile X ◽  
Knockout Mouse Model ◽  
Fmr1 Knockout Mouse

Putting Into Perspective the Use of the Fmr1 Knockout Mouse as a Model for Autism Spectrum Disorder

2013 ◽  
Author(s):  
Richard Paylor ◽  
Alexia M. Thomas ◽  
Surabi Veeraragavan ◽  
Corinne M. Spencer
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Delay ◽  
Fragile X Syndrome ◽  
Knockout Mouse ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fmr1 Gene ◽  
Not Otherwise Specified ◽  
Fmr1 Knockout Mouse

Chapter 7 is concerned with the presence of autism spectrum disorder (ASD) in individuals with Fragile X Syndrome (FXS). It is estimated that 21–50% of individuals with FXS meet the criteria for autism or autism with pervasive developmental delay not otherwise specified. Importantly, recent findings indicate that approximately 2–6% of individuals with ASDs have a mutation in the FMR1 gene, making it one of the most significant single genes associated with the presence of ASD.

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