Enhanced Intracellular Delivery of the Reactive Oxygen Species (ROS)-Generating Copper Chelator D-Penicillamine via a Novel Gelatin−D-Penicillamine Conjugate

2008 ◽  
Vol 19 (7) ◽  
pp. 1382-1388 ◽  
Author(s):  
Anshul Gupte ◽  
Saurabh Wadhwa ◽  
Russell J Mumper
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Copper Chelator

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

2014 ◽  
Vol 53 (49) ◽  
pp. 13444-13448 ◽  
Author(s):  
Ming Wang ◽  
Shuo Sun ◽  
Caleb I. Neufeld ◽  
Bernardo Perez-Ramirez ◽  
Qiaobing Xu
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Protein Modification ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Targeted Cancer Therapy

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

2014 ◽  
Vol 126 (49) ◽  
pp. 13662-13666 ◽  
Author(s):  
Ming Wang ◽  
Shuo Sun ◽  
Caleb I. Neufeld ◽  
Bernardo Perez-Ramirez ◽  
Qiaobing Xu
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Protein Modification ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Targeted Cancer Therapy

Reactive oxygen species (ROS) responsive PEG–PCL nanoparticles with pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin

2015 ◽  
Vol 3 (48) ◽  
pp. 9397-9408 ◽  
Author(s):  
Hongzhang Deng ◽  
Xuefei Zhao ◽  
Jinjian Liu ◽  
Liandong Deng ◽  
Jianhua Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Positive Charge ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Triggered Release ◽  
Charge Reversal ◽  
Active Loading ◽  
Ph Controlled

The charge-conversional behavior and ROS-sensitivity of mPEG-ros-P(CL-co-DCL) NPs for active loading and triggered release of DOX.

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Fas ligand expression in rat kupffer cells in response to lipopolysaccharide is mediated by reactive oxygen species

2001 ◽  
Vol 120 (5) ◽  
pp. A361-A361
Author(s):  
K UCHIKURA ◽  
T WADA ◽  
Z SUN ◽  
S HOSHINO ◽  
G BULKLEY ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Kupffer Cells ◽  
Fas Ligand ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ligand Expression
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