Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

Biochemistry ◽

10.1021/bi00127a021 ◽

1992 ◽

Vol 31 (12) ◽

pp. 3193-3197 ◽

Author(s):

Julie Pitcher ◽

Martin J. Lohse ◽

Juan Codina ◽

Marc G. Caron ◽

Robert J. Lefkowitz

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Adrenergic Receptor ◽

Molecular Mechanisms ◽

Receptor Kinase ◽

Beta Adrenergic Receptor ◽

Dependent Protein Kinase ◽

Kinase C ◽

Dependent Protein ◽

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Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)61475-9 ◽

1987 ◽

Vol 262 (7) ◽

pp. 3106-3113 ◽

Author(s):

M. Bouvier ◽

L.M. Leeb-Lundberg ◽

J.L. Benovic ◽

M.G. Caron ◽

R.J. Lefkowitz

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Adrenergic Receptors ◽

Adrenergic Receptor ◽

Receptor Function ◽

Dependent Protein Kinase ◽

Kinase C ◽

Dependent Protein ◽

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cAMP-dependent protein kinase and protein kinase C consensus site mutations of the beta-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)31615-0 ◽

1994 ◽

Vol 269 (37) ◽

pp. 23032-23038

Author(s):

N. Yuan ◽

J. Friedman ◽

B.S. Whaley ◽

R.B. Clark

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Adrenergic Receptor ◽

Beta Adrenergic Receptor ◽

Dependent Protein Kinase ◽

Beta Adrenergic ◽

Camp Dependent Protein Kinase ◽

Kinase C ◽

Dependent Protein ◽

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Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.88.14.6201 ◽

1991 ◽

Vol 88 (14) ◽

pp. 6201-6204 ◽

Author(s):

N. S. Roth ◽

P. T. Campbell ◽

M. G. Caron ◽

R. J. Lefkowitz ◽

M. J. Lohse

Keyword(s):

Protein Kinase ◽

Adrenergic Receptors ◽

Adrenergic Receptor ◽

Receptor Kinase ◽

Beta Adrenergic Receptors ◽

Beta Adrenergic Receptor ◽

Dependent Protein Kinase ◽

Beta Adrenergic ◽

Dependent Protein

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Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.93.5.2105 ◽

1996 ◽

Vol 93 (5) ◽

pp. 2105-2109 ◽

Author(s):

R. Winstel ◽

S. Freund ◽

C. Krasel ◽

E. Hoppe ◽

M. J. Lohse

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Adrenergic Receptor ◽

Membrane Targeting ◽

Receptor Kinase ◽

Beta Adrenergic Receptor ◽

Beta Adrenergic ◽

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Regulation of D-myo-inositol 1,4,5-trisphosphate 3-kinase by cAMP-dependent protein kinase and protein kinase C.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)86955-1 ◽

1990 ◽

Vol 265 (18) ◽

pp. 10367-10372

Author(s):

S S Sim ◽

J W Kim ◽

S G Rhee

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Kinase C ◽

Inositol 1,4,5 Trisphosphate ◽

Dependent Protein

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Unmasking effect of alamethicin on the (Na+,K+)-ATPase, beta-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)43488-6 ◽

1980 ◽

Vol 255 (20) ◽

pp. 9971-9980 ◽

Author(s):

L.R. Jones ◽

S.W. Maddock ◽

H.R. Besch

Keyword(s):

Protein Kinase ◽

Adenylate Cyclase ◽

Adrenergic Receptor ◽

Beta Adrenergic Receptor ◽

Dependent Protein Kinase ◽

Beta Adrenergic ◽

Camp Dependent Protein Kinase ◽

Dependent Protein ◽

Sarcolemmal Vesicles

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Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)99137-4 ◽

1991 ◽

Vol 266 (17) ◽

pp. 11126-11130

Author(s):

C.J. Palmer ◽

B.T. Scott ◽

L.R. Jones

Keyword(s):

Plasma Membrane ◽

Protein Kinase C ◽

Protein Kinase ◽

Complete Sequence ◽

Sequence Determination ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Kinase C ◽

Dependent Protein

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Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)49909-7 ◽

1991 ◽

Vol 266 (5) ◽

pp. 2753-2758

Author(s):

R L Raynor ◽

B Zheng ◽

J F Kuo

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Polymyxin B ◽

Differential Inhibition ◽

Membrane Interactions ◽

Dependent Protein Kinase ◽

Synaptosomal Membrane ◽

Kinase C ◽

Dependent Protein

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Caldesmon phosphorylation in intact human platelets by cAMP-dependent protein kinase and protein kinase C

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)99039-3 ◽

1991 ◽

Vol 266 (18) ◽

pp. 11876-11881

Author(s):

J.M. Hettasch ◽

J.R. Sellers

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Human Platelets ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Kinase C ◽

Dependent Protein

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The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)74034-4 ◽

1992 ◽

Vol 267 (35) ◽

pp. 25256-25263

Author(s):

H Sugiyama ◽

P Chen ◽

M Hunter ◽

R Taffs ◽

M Sitkovsky

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

T Cell Receptor ◽

Cell Receptor ◽

Alpha Subunit ◽

Dependent Protein Kinase ◽

Effector Functions ◽

Kinase C ◽

Dependent Protein

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