Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblast growth

Biochemistry ◽  
1986 ◽  
Vol 25 (6) ◽  
pp. 1408-1413 ◽  
Author(s):  
Marcelle Miskulin ◽  
Raymond Dalgleish ◽  
Barbara Kluve-Beckerman ◽  
Stephen I. Rennard ◽  
Paul Tolstoshev ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type I Collagen ◽  
Type Iii Collagen ◽  
Type I ◽  
Collagen Gene ◽  
Fibroblast Growth ◽  
Type Iii ◽  
Human Type ◽  
Collagen Gene Expression ◽  
Collagen Genes

Differential expression of type I and type III collagen genes during tooth development

Development ◽  
1991 ◽  
Vol 111 (3) ◽  
pp. 691-698
Author(s):  
M.B. Andujar ◽  
P. Couble ◽  
M.L. Couble ◽  
H. Magloire
Keyword(s):  
Gene Expression ◽  
Type I Collagen ◽  
Tooth Development ◽  
Expression Patterns ◽  
Type Iii Collagen ◽  
Type I ◽  
Collagen Gene ◽  
Type Iii ◽  
Collagen Gene Expression ◽  
Collagen Genes

Collagen gene expression during mouse molar tooth development was studied by quantitative in situ hybridization techniques. Different expression patterns of type I and type III collagen mRNAs were observed in the various mesenchymal tissues that constitute the tooth germ. High concentration for pro-alpha 1(I) and pro-alpha 2(I) collagen mRNAs were found within the osteoblasts. We found that the cellular content of type I collagen mRNAs in the odontoblasts varies throughout the tooth formation: whereas mRNA concentration for pro-alpha 1(I) collagen decreases and that of pro-alpha 2(I) increases, during postnatal development. Moreover, different amounts of pro-alpha 1(I) and pro-alpha 2(I) collagen mRNAs were observed in crown and root odontoblasts, respectively. Type III collagen mRNAs were detected in most of the mesenchymal cells, codistributed with type I collagen mRNAs, except in odontoblasts and osteoblasts. Finally, this study reports differential accumulation of collagen mRNAs during mouse tooth development and points out that type I collagen gene expression is regulated by distinct mechanisms during odontoblast differentiation process. These results support the independent expression of the collagen genes under developmental tissue-specific control.

scholarly journals A Novel Role of Annexin A2 in Human Type I Collagen Gene Expression

2015 ◽  
Vol 116 (3) ◽  
pp. 408-417 ◽  
Author(s):  
Georgia Schäfer ◽  
Jessica K. Hitchcock ◽  
Tamlyn M. Shaw ◽  
Arieh A. Katz ◽  
M. Iqbal Parker
Keyword(s):  
Gene Expression ◽  
Type I Collagen ◽  
Annexin A2 ◽  
Type I ◽  
Collagen Gene ◽  
Human Type ◽  
Collagen Gene Expression

Aberrant type I and type III collagen gene expression in human breast cancerin vivo

1998 ◽  
Vol 186 (3) ◽  
pp. 262-268 ◽  
Author(s):  
Saila Kauppila ◽  
Frej Stenbäck ◽  
Juha Risteli ◽  
Arja Jukkola ◽  
Leila Risteli
Keyword(s):  
Gene Expression ◽  
Type Iii Collagen ◽  
Type I ◽  
Collagen Gene ◽  
Human Breast ◽  
Type Iii ◽  
Collagen Gene Expression

Downregulation of Human Type III Collagen Gene Expression by Antisense Oligodeoxynucleotide

2005 ◽  
Vol 11 (9-10) ◽  
pp. 1429-1435 ◽  
Author(s):  
Fengyan Jia ◽  
Takatoshi Shimomura ◽  
Christopher Niyibizi ◽  
Savio L-Y. Woo
Keyword(s):  
Gene Expression ◽  
Antisense Oligodeoxynucleotide ◽  
Type Iii Collagen ◽  
Collagen Gene ◽  
Type Iii ◽  
Human Type ◽  
Collagen Gene Expression

Tissue specificity of type I collagen gene expression is determined at both transcriptional and post-transcriptional levels

1984 ◽  
Vol 4 (9) ◽  
pp. 1843-1852
Author(s):  
R J Focht ◽  
S L Adams
Keyword(s):  
Gene Expression ◽  
Rna Structure ◽  
Type I Collagen ◽  
Translational Efficiency ◽  
Type I ◽  
Collagen Gene ◽  
Differentiated Cells ◽  
Collagen Gene Expression

We analyzed the control of type I collagen synthesis in four kinds of differentiated cells from chicken embryos which synthesize very different amounts of the protein. Tendon, skin, and smooth muscle cells were found to have identical amounts of type I collagen RNAs; however, the RNAs had inherently different translatabilities, which were observed both in vivo and in vitro. Chondrocytes also had substantial amounts of type I collagen RNAs, even though they directed no detectable synthesis of the protein either in vivo or in vitro. Type I collagen RNAs in chondrocytes display altered electrophoretic mobilities, suggesting that in these cells the reduction in translational efficiency may be mediated in part by changes in the RNA structure. These data indicate that control of type I collagen gene expression is a complex process which is exerted at both transcriptional and post-transcriptional levels.

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