Fatty acid synthase, a proficient multifunctional enzyme

Biochemistry ◽

10.1021/bi00437a001 ◽

1989 ◽

Vol 28 (11) ◽

pp. 4523-4530 ◽

Author(s):

Salih J. Wakil

Keyword(s):

Fatty Acid Synthase ◽

Multifunctional Enzyme

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A QM/MM study of the reaction mechanism of human β-ketoacyl reductase

Physical Chemistry Chemical Physics ◽

10.1039/c6cp07014k ◽

2017 ◽

Vol 19 (1) ◽

pp. 347-355 ◽

Author(s):

Fabiola E. Medina ◽

Rui P. P. Neves ◽

Maria J. Ramos ◽

Pedro A. Fernandes

Keyword(s):

Reaction Mechanism ◽

Fatty Acid Synthase ◽

Biological Functions ◽

Multifunctional Enzyme

Human fatty acid synthase (hFAS) is a multifunctional enzyme involved in a wide diversity of biological functions. We have studied its reaction mechanism with computational QM/MM methods.

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ChemInform Abstract: Structure and Mechanism of Action of a Multifunctional Enzyme: Fatty Acid Synthase

10.1002/chin.199109376 ◽

2010 ◽

Vol 22 (9) ◽

pp. no-no

Author(s):

S.-I. CHANG ◽

G. G. HAMMES

Keyword(s):

Mechanism Of Action ◽

Fatty Acid Synthase ◽

Multifunctional Enzyme ◽

Abstract Structure

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Structure and mechanism of action of a multifunctional enzyme: fatty acid synthase

Accounts of Chemical Research ◽

10.1021/ar00179a003 ◽

1990 ◽

Vol 23 (11) ◽

pp. 363-369 ◽

Author(s):

Soo Ik Chang ◽

Gordon G. Hammes

Keyword(s):

Mechanism Of Action ◽

Fatty Acid Synthase ◽

Multifunctional Enzyme

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Discovery of fatty acid synthase inhibitors and their biosynthetic pathways by a novel target-directed genome mining strategy

Planta Medica ◽

10.1055/s-0035-1556330 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

J Li ◽

X Tang ◽

JJ Zhang ◽

EC O'Neill ◽

SM Mantovani ◽

...

Keyword(s):

Fatty Acid Synthase ◽

Genome Mining ◽

Biosynthetic Pathways ◽

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Dietary whole and cracked linseed increases the proportion of oleic and α-linolenic acids in adipose tissues and decreases stearoyl-coenzyme A desaturase, acetyl-coenzyme A carboxylase, and fatty acid synthase gene expression in the longissimus thoracis muscle of Yanbian Yellow cattle

Journal of Animal Science ◽

10.2527/jas2016.1050 ◽

2017 ◽

Vol 95 (2) ◽

pp. 718

Author(s):

X. Z. Li ◽

C. G. Yan ◽

J. Yu ◽

Q. S. Gao ◽

S. H. Choi ◽

...

Keyword(s):

Gene Expression ◽

Fatty Acid Synthase ◽

Adipose Tissues ◽

Acetyl Coenzyme A ◽

Acetyl Coenzyme ◽

Yellow Cattle ◽

Acetyl Coenzyme A Carboxylase ◽

Fatty Acid Synthase Gene

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Faculty Opinions recommendation of Architecture of mammalian fatty acid synthase at 4.5 A resolution.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031581.367827 ◽

2006 ◽

Author(s):

Xiayang Qiu

Keyword(s):

Fatty Acid Synthase

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Faculty Opinions recommendation of Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1081786.534702 ◽

2007 ◽

Author(s):

Jon Thorson

Keyword(s):

Fatty Acid Synthase

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Faculty Opinions recommendation of Discovery of a regulatory subunit of the yeast fatty acid synthase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737533239.793574066 ◽

2020 ◽

Author(s):

Barbara Imperiali ◽

Greg Dodge

Keyword(s):

Fatty Acid Synthase ◽

Regulatory Subunit

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Inhibitors of Fatty Acid Synthase for Prostate Cancer

10.21236/ada570535 ◽

2012 ◽

Author(s):

Steven J. Kridel

Keyword(s):

Prostate Cancer ◽

Fatty Acid Synthase

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Fatty Acid Synthase Activity as a Target for c-Met Driven Prostate Cancer

10.21236/ada582141 ◽

2013 ◽

Author(s):

David T. Coleman

Keyword(s):

Prostate Cancer ◽

Fatty Acid Synthase

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