Transcription Inhibition of OncogenicKRASby a Mutation-Selective Peptide Nucleic Acid Conjugated to the PKKKRKV Nuclear Localization Signal Peptide†

Biochemistry ◽  
2005 ◽  
Vol 44 (31) ◽  
pp. 10510-10519 ◽  
Author(s):  
S. Cogoi ◽  
A. Codognotto ◽  
V. Rapozzi ◽  
N. Meeuwenoord ◽  
G. van der Marel ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nuclear Localization ◽  
Signal Peptide ◽  
Nuclear Localization Signal ◽  
Peptide Nucleic Acid ◽  
Transcription Inhibition ◽  
Localization Signal

A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA

10.1038/11726 ◽  
1999 ◽  
Vol 17 (8) ◽  
pp. 784-787 ◽  
Author(s):  
Lars J. Brandén ◽  
Abdalla J. Mohamed ◽  
C. I. Edvard Smith
Keyword(s):  
Nucleic Acid ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Peptide Nucleic Acid ◽  
Nuclear Transport ◽  
Signal Fusion ◽  
Localization Signal

No Enhancement of Nuclear Entry by Direct Conjugation of a Nuclear Localization Signal Peptide to Linearized DNA

2003 ◽  
Vol 14 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
Mitsuhide Tanimoto ◽  
Hiroyuki Kamiya ◽  
Noriaki Minakawa ◽  
Akira Matsuda ◽  
Hideyoshi Harashima
Keyword(s):  
Nuclear Localization ◽  
Signal Peptide ◽  
Nuclear Localization Signal ◽  
Nuclear Entry ◽  
Localization Signal

Gene Delivery by PAMAM Dendrimer Conjugated with the Nuclear Localization Signal Peptide Derived from Influenza B Virus Nucleoprotein

2019 ◽  
Vol 27 (4) ◽  
pp. 360-368 ◽  
Author(s):  
Jeil Lee ◽  
Seulgi Lee ◽  
Yong-Eun Kwon ◽  
Youn-Joong Kim ◽  
Joon Sig Choi
Keyword(s):  
Gene Delivery ◽  
Nuclear Localization ◽  
Signal Peptide ◽  
Nuclear Localization Signal ◽  
Pamam Dendrimer ◽  
Influenza B Virus ◽  
Influenza B ◽  
B Virus ◽  
Localization Signal

scholarly journals In Silico Analysis: Annotations about Structural and Functional Features of DUF 2726 Family Member Proteins

2016 ◽  
pp. 53-58
Author(s):  
SM Sabbir Alam ◽  
M Ruhul Amin ◽  
M Anwar Hossain
Keyword(s):  
Nucleic Acid ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Bacterial Species ◽  
Nucleic Acid Binding ◽  
Protein Families ◽  
Binding Properties ◽  
Pfam Database ◽  
Localization Signal ◽  
Functional Features

Domains of unknown functions (DUFs) are a big set of protein families within the Pfam database that includes proteins of unknown function. In the absence of functional information, proteins are classified into different families based on conserved amino acid sequences and are potentially functionally important. In Pfam database, the numbers of families of DUFs are rapidly increasing and in current the fraction of DUF families had increased to about twenty two percent of all protein families. In this study we targeted DUF2726 member proteins which are mainly present in different bacterial species of Gamma-proteobacteria and have a particular domain organization. We analyzed the protein sequences of domain DUF2726 using different computational tools and databases. We found that this domain contains a nuclear localization signal peptide, which is conserved in Escherichia spp. and Shigella spp. It were also predicted that it has nucleic acid binding properties. Analyzing protein-protein interactions functional partners associated with DUF 2726 were revealed. Protein secondary structure, transmembrane helices structure were predicted. We have found that it has gene neighbourhood and co-occurrences with protein RepA and RepB. RepA and RepB are functionally associated with replication. RepA is a replication protein and RepB is a replication regulatory protein. Presence of a nucleic acid binding properties, a nuclear localization signal (NLS) signalling peptide, and possible interaction pattern with replication proteins, conjectures its possible role as a NLS like signalling peptide.Bangladesh J Microbiol, Volume 31, Number 1-2,June-Dec 2014, pp 53-58

One pot synthesis of highly luminescent polyethylene glycol anchored carbon dots functionalized with a nuclear localization signal peptide for cell nucleus imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6104-6113 ◽  
Author(s):  
Lei Yang ◽  
Weihua Jiang ◽  
Lipeng Qiu ◽  
Xuewei Jiang ◽  
Daiying Zuo ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Nuclear Localization ◽  
Signal Peptide ◽  
Cell Nucleus ◽  
Nuclear Localization Signal ◽  
Carbon Dots ◽  
One Pot ◽  
One Pot Synthesis ◽  
Localization Signal
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