scholarly journals Mechanism of Adenomatous Polyposis Coli (APC)-Mediated Blockage of Long-Patch Base Excision Repair†

Biochemistry ◽  
2006 ◽  
Vol 45 (51) ◽  
pp. 15903-15914 ◽  
Author(s):  
Aruna S. Jaiswal ◽  
Ramesh Balusu ◽  
Melissa L. Armas ◽  
Chanakya N. Kundu ◽  
Satya Narayan
Keyword(s):  
Adenomatous Polyposis Coli ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Base Excision

Structure/Function Analysis of the Interaction of Adenomatous Polyposis Coli with DNA Polymerase β and Its Implications for Base Excision Repair†

Biochemistry ◽  
2007 ◽  
Vol 46 (49) ◽  
pp. 13961-13974 ◽  
Author(s):  
Ramesh Balusu ◽  
Aruna S. Jaiswal ◽  
Melissa L. Armas ◽  
Chanakya N. Kundu ◽  
Linda B. Bloom ◽  
...  
Keyword(s):  
Structure Function ◽  
Adenomatous Polyposis Coli ◽  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Function Analysis ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Dna Polymerase Β ◽  
Base Excision

ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli

DNA Repair ◽  
2016 ◽  
Vol 45 ◽  
pp. 44-55 ◽  
Author(s):  
Sumit Siddharth ◽  
Deepika Nayak ◽  
Anmada Nayak ◽  
Sarita Das ◽  
Chanakya Nath Kundu
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Metastatic Breast ◽  
Breast Cancer Stem Cells ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Base Excision ◽  
Induced Apoptosis

scholarly journals 5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway

DNA Repair ◽  
2014 ◽  
Vol 24 ◽  
pp. 15-25 ◽  
Author(s):  
Dipon Das ◽  
Ranjan Preet ◽  
Purusottam Mohapatra ◽  
Shakti Ranjan Satapathy ◽  
Sumit Siddharth ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Colon Cancer Cells ◽  
Repair Pathway ◽  
Polyposis Coli ◽  
Anti Cancer ◽  
Base Excision ◽  
Cancer Activity

MutYH (MYH) and colorectal cancer

2005 ◽  
Vol 33 (4) ◽  
pp. 679-683 ◽  
Author(s):  
J.R. Sampson ◽  
S. Jones ◽  
S. Dolwani ◽  
J.P. Cheadle
Keyword(s):  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Ras Genes ◽  
Stable Product ◽  
Base Excision ◽  
Mutyh Associated Polyposis ◽  
Inherited Mutations ◽  
Oxidative Damage To Dna

MAP (MutYH-associated polyposis) is a recently described colorectal adenoma and carcinoma predisposition syndrome that is associated with biallelic-inherited mutations of the human MutY homologue gene, MutYH. MutYH is often also termed MYH. MAP tumours display a mutational signature of somatic guanine-to-thymine transversion mutations in the adenomatous polyposis coli and K-ras genes, reflecting the normal role of MutYH in the base excision repair of adenines misincorporated opposite 7,8-dihydro-8-oxoguanine, a prevalent and stable product of oxidative damage to DNA. However, the full genetic pathway of MAP tumorigenesis has not been elucidated.

A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer

2015 ◽  
Vol 47 (6) ◽  
pp. 668-671 ◽  
Author(s):  
Robbert D A Weren ◽  
Marjolijn J L Ligtenberg ◽  
C Marleen Kets ◽  
Richarda M de Voer ◽  
Eugène T P Verwiel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Homozygous Mutation ◽  
Adenomatous Polyposis ◽  
Repair Gene ◽  
Base Excision
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