Isotropic Bicelles Stabilize the Juxtamembrane Region of the Influenza M2 Protein for Solution NMR Studies

Biochemistry ◽  
2013 ◽  
Vol 52 (47) ◽  
pp. 8420-8429 ◽  
Author(s):  
Jolyon K. Claridge ◽  
Jussi Aittoniemi ◽  
Daniel M. Cooper ◽  
Jason R. Schnell
Keyword(s):  
Solution Nmr ◽  
M2 Protein ◽  
Nmr Studies ◽  
Juxtamembrane Region

NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins

2018 ◽  
Vol 69 (7) ◽  
pp. 1838-1841
Author(s):  
Hajnal Kelemen ◽  
Angella Csillag ◽  
Bela Noszal ◽  
Gabor Orgovan
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Water Solubility ◽  
Solution Nmr ◽  
Spectroscopic Techniques ◽  
Nmr Studies ◽  
The Poor ◽  
Poor Water Solubility

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.

scholarly journals Solution NMR Studies of Antiamoebin, a Membrane Channel-Forming Polypeptide

2003 ◽  
Vol 84 (1) ◽  
pp. 185-194 ◽  
Author(s):  
T.P. Galbraith ◽  
R. Harris ◽  
P.C. Driscoll ◽  
B.A. Wallace
Keyword(s):  
Solution Nmr ◽  
Membrane Channel ◽  
Nmr Studies

scholarly journals Slow Exchange Model of Nonrigid Rotational Motion in RNA for Combined Solid-State and Solution NMR Studies

2010 ◽  
Vol 114 (48) ◽  
pp. 15991-16002 ◽  
Author(s):  
Prashant S. Emani ◽  
Gregory L. Olsen ◽  
Dorothy C. Echodu ◽  
Gabriele Varani ◽  
Gary P. Drobny
Keyword(s):  
Solid State ◽  
Rotational Motion ◽  
Exchange Model ◽  
Solution Nmr ◽  
Nmr Studies ◽  
Slow Exchange

scholarly journals Solution NMR Studies of Chlorella Virus DNA Ligase-adenylate

2010 ◽  
Vol 395 (2) ◽  
pp. 291-308 ◽  
Author(s):  
Andrea Piserchio ◽  
Pravin A. Nair ◽  
Stewart Shuman ◽  
Ranajeet Ghose
Keyword(s):  
Solution Nmr ◽  
Dna Ligase ◽  
Nmr Studies ◽  
Chlorella Virus

Topology of an Outer-Membrane Enzyme:  Measuring Oxygen and Water Contacts in Solution NMR Studies of PagP

2006 ◽  
Vol 128 (25) ◽  
pp. 8256-8264 ◽  
Author(s):  
Ferenc Evanics ◽  
Peter M. Hwang ◽  
Yao Cheng ◽  
Lewis E. Kay ◽  
R. Scott Prosser
Keyword(s):  
Outer Membrane ◽  
Solution Nmr ◽  
Nmr Studies ◽  
Membrane Enzyme

Synthetic Biology-Based Solution NMR Studies on Membrane Proteins in Lipid Environments

2019 ◽  
pp. 143-185 ◽  
Author(s):  
Erik Henrich ◽  
Frank Löhr ◽  
Julija Mezhyrova ◽  
Aisha Laguerre ◽  
Frank Bernhard ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Membrane Proteins ◽  
Solution Nmr ◽  
Nmr Studies

scholarly journals C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix

2015 ◽  
Vol 24 (3) ◽  
pp. 426-429 ◽  
Author(s):  
Shenstone Huang ◽  
Bryan Green ◽  
Megan Thompson ◽  
Richard Chen ◽  
Jessica Thomaston ◽  
...  
Keyword(s):  
Membrane Surface ◽  
Full Length ◽  
Amphipathic Helix ◽  
M2 Protein ◽  
Juxtamembrane Region

Solid-State and Solution NMR Studies of the CAP-Gly Domain of Mammalian Dynactin and Its Interaction with Microtubules

2009 ◽  
Vol 131 (29) ◽  
pp. 10113-10126 ◽  
Author(s):  
Shangjin Sun ◽  
Amanda Siglin ◽  
John C. Williams ◽  
Tatyana Polenova
Keyword(s):  
Solid State ◽  
Solution Nmr ◽  
Nmr Studies

Solution NMR studies of the plant peptide hormone CEP inform function

FEBS Letters ◽  
2013 ◽  
Vol 587 (24) ◽  
pp. 3979-3985 ◽  
Author(s):  
Benjamin G. Bobay ◽  
Peter DiGennaro ◽  
Elizabeth Scholl ◽  
Nijat Imin ◽  
Michael A. Djordjevic ◽  
...  
Keyword(s):  
Peptide Hormone ◽  
Solution Nmr ◽  
Nmr Studies
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