Biotinylated Polyacrylamide-Based Metal-Chelating Polymers and Their Influence on Antigen Recognition Following Conjugation to a Trastuzumab Fab Fragment

2012 ◽  
Vol 13 (9) ◽  
pp. 2831-2842 ◽  
Author(s):  
Peng Liu ◽  
Amanda J. Boyle ◽  
Yijie Lu ◽  
Raymond M. Reilly ◽  
Mitchell A. Winnik
Keyword(s):  
Antigen Recognition ◽  
Fab Fragment ◽  
Metal Chelating ◽  
Chelating Polymers

Site-Specific Conjugation of Metal-Chelating Polymers to Anti-Frizzled-2 Antibodies via Microbial Transglutaminase

2021 ◽  
Author(s):  
Penny J. Le ◽  
Shane Miersch ◽  
Matthew W. Forbes ◽  
Nick Jarvik ◽  
Anthony Ku ◽  
...  
Keyword(s):  
Microbial Transglutaminase ◽  
Site Specific ◽  
Metal Chelating ◽  
Chelating Polymers

scholarly journals EGFR-Targeted Metal Chelating Polymers (MCPs) Harboring Multiple Pendant PEG2K Chains for MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts

2017 ◽  
Vol 3 (3) ◽  
pp. 279-290 ◽  
Author(s):  
Yijie Lu ◽  
Amanda J. Boyle ◽  
Ping-Jiang Cao ◽  
David Hedley ◽  
Raymond M. Reilly ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Ct Imaging ◽  
Metal Chelating ◽  
Chelating Polymers

Metal-Chelating Polymers by Anionic Ring-Opening Polymerization and Their Use in Quantitative Mass Cytometry

2012 ◽  
Vol 13 (8) ◽  
pp. 2359-2369 ◽  
Author(s):  
Nicolas Illy ◽  
Daniel Majonis ◽  
Isaac Herrera ◽  
Olga Ornatsky ◽  
Mitchell A. Winnik
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Mass Cytometry ◽  
Metal Chelating ◽  
Anionic Ring ◽  
Chelating Polymers

Assessing the effects of model Maillard compound intake on iron, copper and zinc retention and tissue delivery in adult rats

2016 ◽  
Vol 7 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Irene Roncero-Ramos ◽  
Silvia Pastoriza ◽  
M. Pilar Navarro ◽  
Cristina Delgado-Andrade
Keyword(s):  
Maillard Reaction ◽  
Adult Rats ◽  
Mineral Absorption ◽  
Metal Chelating ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Retention ◽  
Chelating Polymers

The behaviour of dietary Maillard reaction compounds (MRP) as metal chelating polymers can alter mineral absorption and/or retention.

Metal-Chelating Polymers (MCPs) with Zwitterionic Pendant Groups Complexed to Trastuzumab Exhibit Decreased Liver Accumulation Compared to Polyanionic MCP Immunoconjugates

2015 ◽  
Vol 16 (11) ◽  
pp. 3613-3623 ◽  
Author(s):  
Peng Liu ◽  
Amanda J. Boyle ◽  
Yijie Lu ◽  
Jarrett Adams ◽  
Yuechuan Chi ◽  
...  
Keyword(s):  
Metal Chelating ◽  
Chelating Polymers

Stability and Biodistribution of Thiol-Functionalized and177Lu-Labeled Metal Chelating Polymers Bound to Gold Nanoparticles

2016 ◽  
Vol 17 (4) ◽  
pp. 1292-1302 ◽  
Author(s):  
Simmyung Yook ◽  
Yijie Lu ◽  
Jenny Jooyoung Jeong ◽  
Zhongli Cai ◽  
Lemuel Tong ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Metal Chelating ◽  
Chelating Polymers

Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to177Lu

2018 ◽  
Vol 16 (2) ◽  
pp. 768-778 ◽  
Author(s):  
Sadaf Aghevlian ◽  
Zhongli Cai ◽  
Yijie Lu ◽  
David W. Hedley ◽  
Mitchell A. Winnik ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Human Pancreatic Cancer ◽  
Metal Chelating ◽  
Chelating Polymers

scholarly journals The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Fu-Lien Hsieh ◽  
Matthew K Higgins
Keyword(s):  
Immune Cell ◽  
Adaptive Immune System ◽  
Antigen Recognition ◽  
Binding Potential ◽  
Human Antibody ◽  
Antigen Binding ◽  
Antigen Binding Site ◽  
Fab Fragment ◽  
Cell Recruitment ◽  
Critical Components

Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the heavy and light chain each providing three hypervariable loops, which are varied to generate diversity. The recent identification of a novel class of antibody in humans from malaria endemic regions of Africa was therefore surprising as one hypervariable loop contains the entire collagen-binding domain of human LAIR1. Here, we present the structure of the Fab fragment of such an antibody. We show that its antigen-binding site has adopted an architecture that positions LAIR1, while itself being occluded. This therefore represents a novel means of antigen recognition, in which the Fab fragment of an antibody acts as an adaptor, linking a human protein insert with antigen-binding potential to the constant antibody regions which mediate immune cell recruitment.

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