scholarly journals Combining Topographical and Genetic Cues to Promote Neuronal Fate Specification in Stem Cells

2012 ◽  
Vol 13 (11) ◽  
pp. 3427-3438 ◽  
Author(s):  
Erin K. Purcell ◽  
Youssef Naim ◽  
Amy Yang ◽  
Michelle K. Leach ◽  
J. Matthew Velkey ◽  
...  
Keyword(s):  
Stem Cells ◽  
Fate Specification ◽  
Neuronal Fate ◽  
Neuronal Fate Specification

scholarly journals Neuronal fate specification by the Dbx1 transcription factor is linked to the evolutionary acquisition of a novel functional domain

EvoDevo ◽  
2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Sonia Karaz ◽  
Maximilien Courgeon ◽  
Hélène Lepetit ◽  
Eugenia Bruno ◽  
Raimondo Pannone ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Functional Domain ◽  
Fate Specification ◽  
Neuronal Fate ◽  
Neuronal Fate Specification

scholarly journals Genetic Screens forCaenorhabditis elegansMutants Defective in Left/Right Asymmetric Neuronal Fate Specification

Genetics ◽  
2007 ◽  
Vol 176 (4) ◽  
pp. 2109-2130 ◽  
Author(s):  
Sumeet Sarin ◽  
M. Maggie O'Meara ◽  
Eileen B. Flowers ◽  
Celia Antonio ◽  
Richard J. Poole ◽  
...  
Keyword(s):  
Genetic Screens ◽  
Fate Specification ◽  
Neuronal Fate ◽  
Neuronal Fate Specification

scholarly journals Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Jing Zhao ◽  
Quan Lin ◽  
Kevin J Kim ◽  
Faranak D Dardashti ◽  
Jennifer Kim ◽  
...  
Keyword(s):  
Cell Fate ◽  
Epigenetic Regulation ◽  
In Vitro Study ◽  
Fate Specification ◽  
Neuronal Fate ◽  
Non Coding Rna ◽  
Neuronal Fate Specification ◽  
Stat Pathway

It has been postulated that a proneural factor, neurogenin 1 (Ngn1), simultaneously activates the neurogenic program and inhibits the alternative astrogliogenic program when specifying the neuronal fate. While Ngn1 substantially suppresses the activation of the astrogliogenic Jak-Stat pathway, the underlying molecular mechanism was unknown. Here, by employing in vivo and in vitro approaches, we report that Ngn1 binds to the promoter of a brain-enriched microRNA, miR-9, and activates its expression during neurogenesis. Subsequently, our in vitro study showed that miR-9 directly targets mRNAs of Lifr-beta, Il6st (gp130), and Jak1 to down-regulate these critical upstream components of the Jak-Stat pathway, achieving inhibition of Stat phosphorylation and consequently, suppression of astrogliogenesis. This study revealed Ngn1 modulated non-coding RNA epigenetic regulation during cell fate specifications.

scholarly journals The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila

PLoS Genetics ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. e1009894
Author(s):  
Qingliang Sang ◽  
Gang Wang ◽  
David B. Morton ◽  
Hui Wu ◽  
Baotong Xie
Keyword(s):  
Hippo Pathway ◽  
Hippo Signaling ◽  
Fate Specification ◽  
Upstream Regulator ◽  
Neuronal Fate ◽  
Zonula Occludens ◽  
Pathway Activation ◽  
Core Components ◽  
The Hippo Pathway ◽  
Neuronal Fate Specification

The generation of a diversity of photoreceptor (PR) subtypes with different spectral sensitivities is essential for color vision in animals. In the Drosophila eye, the Hippo pathway has been implicated in blue- and green-sensitive PR subtype fate specification. Specifically, Hippo pathway activation promotes green-sensitive PR fate at the expense of blue-sensitive PRs. Here, using a sensitized triple heterozygote-based genetic screening approach, we report the identification of the single Drosophila zonula occludens-1 (ZO-1) protein Polychaetoid (Pyd) as a new regulator of the Hippo pathway during the blue- and green-sensitive PR subtype binary fate choice. We demonstrate that Pyd acts upstream of the core components and the upstream regulator Pez in the Hippo pathway. Furthermore, We found that Pyd represses the activity of Su(dx), a E3 ligase that negatively regulates Pez and can physically interact with Pyd, during PR subtype fate specification. Together, our results identify a new mechanism underlying the Hippo signaling pathway in post-mitotic neuronal fate specification.

scholarly journals Endocannabinoid Signaling Alters Internal Programming of Neuronal Fate Specification

2013 ◽  
Vol 33 (13) ◽  
pp. 5437-5438
Author(s):  
E. B. Sequerra ◽  
S. Cates ◽  
M. Moreno ◽  
J. Lang ◽  
L. A. Orosco ◽  
...  
Keyword(s):  
Fate Specification ◽  
Neuronal Fate ◽  
Neuronal Fate Specification
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