Design of a Tubular Loop Bioreactor for Scale-up and Scale-down of Fermentation Processes

2003 ◽  
Vol 19 (5) ◽  
pp. 1498-1504 ◽  
Author(s):  
M. Papagianni ◽  
M. Mattey ◽  
B. Kristiansen
Keyword(s):  
Scale Up ◽  
Fermentation Processes ◽  
Scale Down

scholarly journals Maintaining paediatric cardiac services during the COVID-19 pandemic in a developing country in sub-Saharan Africa: guidelines for a “scale up” in the face of a global “scale down”

2020 ◽  
Vol 30 (11) ◽  
pp. 1588-1594
Author(s):  
Ogochukwu J. Sokunbi ◽  
Ogadinma Mgbajah ◽  
Augustine Olugbemi ◽  
Bassey O. Udom ◽  
Ariyo Idowu ◽  
...  
Keyword(s):  
Scale Up ◽  
Global Scale ◽  
International Travel ◽  
Sub Saharan Africa ◽  
African Continent ◽  
Tertiary Centre ◽  
The Face ◽  
Scale Down ◽  
Sub Saharan ◽  
International Experts

AbstractThe COVID-19 pandemic is currently ravaging the globe and the African continent is not left out. While the direct effects of the pandemic in regard to morbidity and mortality appear to be more significant in the developed world, the indirect harmful effects on already insufficient healthcare infrastructure on the African continent would in the long term be more detrimental to the populace. Women and children form a significant vulnerable population in underserved areas such as the sub-Saharan region, and expectedly will experience the disadvantages of limited healthcare coverage which is a major fall out of the pandemic. Paediatric cardiac services that are already sparse in various sub-Saharan countries are not left out of this downsizing. Restrictions on international travel for patients out of the continent to seek medical care and for international experts into the continent for regular mission programmes leave few options for children with cardiac defects to get the much-needed care.There is a need for a region-adapted guideline to scale-up services to cater for more children with congenital heart disease (CHD) while providing a safe environment for healthcare workers, patients, and their caregivers. This article outlines measures adapted to maintain paediatric cardiac care in a sub-Saharan tertiary centre in Nigeria during the COVID-19 pandemic and will serve as a guide for other institutions in the region who will inadvertently need to provide these services as the demand increases.

Scale-up and application of a cyclone reactor for fermentation processes

1998 ◽  
Vol 18 (6) ◽  
pp. 433 ◽  
Author(s):  
D. Weuster-Botz ◽  
E. Hünnekes ◽  
A. Hartbrich
Keyword(s):  
Scale Up ◽  
Fermentation Processes

Scale-up and scale-down techniques for fermentations of polyene antibiotics

1990 ◽  
Vol 55 (7) ◽  
pp. 1730-1740 ◽  
Author(s):  
Petr Ettler
Keyword(s):  
Dehydrogenase Activity ◽  
Scale Up ◽  
Scaling Up ◽  
Industrial Scale ◽  
Laboratory Findings ◽  
Polyene Antibiotics ◽  
Activity Determination ◽  
Simultaneous Control ◽  
Streptomyces Noursei ◽  
Scale Down

Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenase activity determination. The utility of scale-down tests for identification of process fluctuation, validation of new substrate batches and simultaneous control of inoculum quality was proved.

scholarly journals Strengths, weaknesses, opportunities, threats analysis on choice of multi chamber bag or compounded parenteral nutrition

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2298-2303
Author(s):  
Sahar Elnajjar ◽  
Dixon Thomas ◽  
Osama Tabbara ◽  
Danial Baker
Keyword(s):  
Decision Making ◽  
Parenteral Nutrition ◽  
Swot Analysis ◽  
Scale Up ◽  
Multiple Stakeholders ◽  
Scale Down ◽  
Internal And External Factors ◽  
The Impact

Reasons for choosing parenteral nutrition (PN) products depend on healthcare institutions internal and external factors. A decision to start, continue, scale-up, scale down, or stop compounding of PN involves multiple stakeholders. This study is an effort to analyze such factors and recommendations on decision-making. A strength, weakness, opportunities, threats (SWOT) analysis was prepared in consultation with major PN providers in the UAE and comparing to international best practices. Based on the SWOT analysis, a set of recommendations was prepared using the GRADE system (classification of quality of evidence and strength of recommendation). Feedback on the SWOT analysis and recommendations were collected from the PN providers. The SWOT analysis and recommendations address aspects of the choice of MCB-PN or compounded PN. It includes considerations on PN indication, availability of ingredients, types of patients, safety, and cost management with labor, automation, and outsourcing. It was received well. The SWOT analysis and recommendations are useful in decision-making in complex therapy like PN. It helps in institutional decisions on choices of MCB-PN or compounded PN. The impact of the recommendations is to be measured in the future.

scholarly journals Cell-free protein synthesis: advances on production process for biopharmaceuticals and immunobiological products

BioTechniques ◽  
2021 ◽  
Vol 70 (2) ◽  
pp. 126-133
Author(s):  
Camila Hiromi Chiba ◽  
Marcos Camargo Knirsch ◽  
Adriano Rodrigues Azzoni ◽  
Antonio R Moreira ◽  
Marco Antonio Stephano
Keyword(s):  
Protein Synthesis ◽  
Production Process ◽  
Scale Up ◽  
Pharmaceutical Market ◽  
Free Protein ◽  
Recent Advances ◽  
Scale Down ◽  
Key Aspects ◽  
Cell Free Protein Synthesis

Biopharmaceutical products are of great importance in the treatment or prevention of many diseases and represent a growing share of the global pharmaceutical market. The usual technology for protein synthesis (cell-based expression) faces certain obstacles, especially with ‘difficult-to-express’ proteins. Cell-free protein synthesis (CFPS) can overcome the main bottlenecks of cell-based expression. This review aims to present recent advances in the production process of biologic products by CFPS. First, key aspects of CFPS systems are summarized. A description of several biologic products that have been successfully produced using the CFPS system is provided. Finally, the CFPS system's ability to scale up and scale down, its main limitations and its application for biologics production are discussed.

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