scholarly journals Attenuation of Quorum Sensing in the PathogenAcinetobacter baumanniiUsing Non-nativeN-Acyl Homoserine Lactones

2012 ◽  
Vol 7 (10) ◽  
pp. 1719-1728 ◽  
Author(s):  
Danielle M. Stacy ◽  
Michael A. Welsh ◽  
Philip N. Rather ◽  
Helen E. Blackwell
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones

Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity

2018 ◽  
Vol 77 ◽  
pp. 215-222 ◽  
Author(s):  
Si-Zhe Li ◽  
Rui Xu ◽  
Mohammed Ahmar ◽  
Catherine Goux-Henry ◽  
Yves Queneau ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones

scholarly journals Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity

2020 ◽  
Vol 11 ◽  
Author(s):  
Garance Coquant ◽  
Jean-Pierre Grill ◽  
Philippe Seksik
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Gut Immunity

scholarly journals Insights from the Genome Sequence of Quorum-Quenching Staphylococcus sp. Strain AL1, Isolated from Traditional Chinese Soy Sauce Brine Fermentation

2012 ◽  
Vol 194 (23) ◽  
pp. 6611-6612 ◽  
Author(s):  
Teik-Min Chong ◽  
Hun-Jiat Tung ◽  
Wai-Fong Yin ◽  
Kok-Gan Chan
Keyword(s):  
Quorum Sensing ◽  
Genome Sequence ◽  
Draft Genome ◽  
Quorum Quenching ◽  
Soy Sauce ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Content Type ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones

ABSTRACTWe report the draft genome sequence ofStaphylococcussp. strain AL1, which degrades quorum-sensing molecules (namely,N-acyl homoserine lactones). To the best of our knowledge, this is the first documentation that reports the whole genome sequence and quorum-quenching activity ofStaphylococcussp. strain AL1.

scholarly journals Burkholderia pseudomallei, B. thailandensis, and B. ambifaria Produce 4-Hydroxy-2-Alkylquinoline Analogues with a Methyl Group at the 3 Position That Is Required for Quorum-Sensing Regulation

2008 ◽  
Vol 190 (15) ◽  
pp. 5339-5352 ◽  
Author(s):  
Ludovic Vial ◽  
François Lépine ◽  
Sylvain Milot ◽  
Marie-Christine Groleau ◽  
Valérie Dekimpe ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Burkholderia Cepacia ◽  
Burkholderia Pseudomallei ◽  
Alkyl Chain ◽  
Quinoline Ring ◽  
Liquid Chromatography Mass Spectrometry ◽  
Methyl Group ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Oxide Group

ABSTRACT 4-Hydroxy-2-alkylquinolines (HAQs), especially 3,4-dihydroxy-2-heptylquinoline (Pseudomonas quinolone signal) and its precursor, 4-hydroxy-2-heptylquinoline, are attracting much attention, mainly because of their role as signaling molecules in Pseudomonas aeruginosa. The pqsABCDE operon is centrally involved in their biosynthesis. The presence of a homologous operon in Burkholderia pseudomallei and B. thailandensis was recently reported. Thus, we have investigated the abilities of 11 Burkholderia species to produce HAQ-like molecules by liquid chromatography/mass spectrometry. We have identified 29 different HAQ derivatives produced by the only three Burkholderia species where a pqsABCDE homologue was found among available sequenced Burkholderia species genomes, including B. ambifaria, a member of the Burkholderia cepacia complex. In contrast with those of P. aeruginosa, Burkholderia HAQs typically bear a methyl group, hence their designation as 4-hydroxy-3-methyl-2-alkylquinolines (HMAQs). We identified three families of HMAQs with a saturated or unsaturated alkyl chain at the 2′ position, in contrast with the 1′ position of P. aeruginosa, including one with an N-oxide group. Furthermore, the operon in these species contains two more genes downstream of the pqsE homologue, resulting in the hmqABCDEFG operon. While the inactivation of hmqA inhibits the production of HMAQs, the methylation of the quinoline ring requires a putative methyltransferase encoded by hmqG. Interestingly, hmqA or hmqG mutations increase the production of acyl homoserine lactones and, consequently, phenotypes under the control of quorum sensing in B. ambifaria: antifungal activity, siderophore production, and proteolytic activity. These results indicate that only HAQs bearing a methyl group (HMAQs) are involved in quorum-sensing regulation.

Sign in / Sign up

Export Citation Format

Share Document