Identification of Novel Amino Acid Derived CCK-2R Antagonists As Potential Antiulcer Agent: Homology Modeling, Design, Synthesis, and Pharmacology

2013 ◽  
Vol 53 (1) ◽  
pp. 176-187 ◽  
Author(s):  
Amit K. Gupta ◽  
Kanika Varshney ◽  
Neetu Singh ◽  
Vaibhav Mishra ◽  
Mridula Saxena ◽  
...  
Keyword(s):  
Amino Acid ◽  
Homology Modeling ◽  
Design Synthesis ◽  
Antiulcer Agent

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

ChemInform Abstract: Design, Synthesis, SAR, and Biological Evaluation of Highly Potent Benzimidazole-Spaced Phosphono-α-amino Acid Competitive NMDA Antagonists of the AP-6 Type.

ChemInform ◽  
2010 ◽  
Vol 32 (35) ◽  
pp. no-no
Author(s):  
Reinhardt B. Baudy ◽  
Horace Fletcher III ◽  
John P. Yardley ◽  
Margaret M. Zaleska ◽  
Donna R. Bramlett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biological Evaluation ◽  
Nmda Antagonists ◽  
Design Synthesis ◽  
Competitive Nmda Antagonists

scholarly journals The Structural Characterization and Antipathogenic Activities of Quinoin, a Type 1 Ribosome-Inactivating Protein from Quinoa Seeds

2021 ◽  
Vol 22 (16) ◽  
pp. 8964
Author(s):  
Sara Ragucci ◽  
Daniela Bulgari ◽  
Nicola Landi ◽  
Rosita Russo ◽  
Angela Clemente ◽  
...  
Keyword(s):  
Amino Acid ◽  
Homology Modeling ◽  
Peptide Mapping ◽  
Cryphonectria Parasitica ◽  
Tobacco Necrosis Virus ◽  
Amino Acid Residues ◽  
Ribosome Inactivating Protein ◽  
Defensive Role

Quinoin is a type 1 ribosome-inactivating protein (RIP) we previously isolated from the seeds of pseudocereal quinoa (Chenopodium quinoa) and is known as a functional food for its beneficial effects on human health. As the presence of RIPs in edible plants could be potentially risky, here we further characterised biochemically the protein (complete amino acid sequence, homologies/differences with other RIPs and three-dimensional homology modeling) and explored its possible defensive role against pathogens. Quinoin consists of 254 amino acid residues, without cysteinyl residues. As demonstrated by similarities and homology modeling, quinoin preserves the amino acid residues of the active site (Tyr75, Tyr122, Glu177, Arg180, Phe181 and Trp206; quinoin numbering) and the RIP-fold characteristic of RIPs. The polypeptide chain of quinoin contains two N-glycosylation sites at Asn115 and Asp231, the second of which appears to be linked to sugars. Moreover, by comparative MALDI-TOF tryptic peptide mapping, two differently glycosylated forms of quinoin, named pre-quinoin-1 and pre-quinoin-2 (~0.11 mg/100 g and ~0.85 mg/100 g of seeds, respectively) were characterised. Finally, quinoin possesses: (i) strong antiviral activity, both in vitro and in vivo towards Tobacco Necrosis Virus (TNV); (ii) a growth inhibition effect on the bacterial pathogens of plants; and (iii) a slight antifungal effect against two Cryphonectria parasitica strains.

Design, synthesis, and partial characterization of water-soluble .beta.-sheets stabilized by a dibenzofuran-based amino acid

1993 ◽  
Vol 115 (9) ◽  
pp. 3790-3791 ◽  
Author(s):  
Humberto Diaz ◽  
Kwok Yin Tsang ◽  
Danny Choo ◽  
Jose R. Espina ◽  
Jeffery W. Kelly
Keyword(s):  
Amino Acid ◽  
Beta Sheets ◽  
Water Soluble ◽  
Partial Characterization ◽  
Design Synthesis

Design, Synthesis and Insecticidal Evaluation of Anthranilic Diamides Containing Optically Pure Amino Acid Moiety

2016 ◽  
Vol 34 (12) ◽  
pp. 1218-1224 ◽  
Author(s):  
Shaa Zhou ◽  
Sha Zhou ◽  
Xuewen Hua ◽  
Wei Wei ◽  
Yongtao Xie ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Moiety ◽  
Design Synthesis ◽  
Amino Acid Moiety ◽  
Pure Amino Acid ◽  
Optically Pure
Sign in / Sign up

Export Citation Format

Share Document