Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transporter Kinetics in Vivo

2014 ◽  
Vol 6 (9) ◽  
pp. 1509-1516 ◽  
Author(s):  
Christopher W. Atcherley ◽  
Nicholas D. Laude ◽  
Eric B. Monroe ◽  
Kevin M. Wood ◽  
Parastoo Hashemi ◽  
...  
1999 ◽  
Vol 26 (8) ◽  
pp. 897-903 ◽  
Author(s):  
David Stout ◽  
Andrej Petric ◽  
N. Satyamurthy ◽  
Quan Nguyen ◽  
Sung-Cheng Huang ◽  
...  
Keyword(s):  

2012 ◽  
Vol 224 (2) ◽  
pp. 337-345 ◽  
Author(s):  
Marcelo Q. Hoexter ◽  
Gustavo Fadel ◽  
André C. Felício ◽  
Mariana B. Calzavara ◽  
Ilza R. Batista ◽  
...  

2009 ◽  
Vol 19 (16) ◽  
pp. 4843-4845 ◽  
Author(s):  
Magnus Schou ◽  
Carsten Steiger ◽  
Andrea Varrone ◽  
Denis Guilloteau ◽  
Christer Halldin

2001 ◽  
Vol 90 (04) ◽  
pp. 198-203 ◽  
Author(s):  
LV Bonamin ◽  
KS Martinho ◽  
AL Nina ◽  
F Caviglia ◽  
RGW Do Rio

AbstractWe evaluated the interaction of dexamethasone 10−17 and 10−33 M (equivalent to 7cH and 15cH) with dexamethasone in pharmacological concentrations, using as experimental models: acute inflammation induced by carrageenan, Ehrlich ascitic tumour, and migration of tumour infiltrating leukocytes (TIL). Male adult BALB/c mice (n=7 per group) were used in all experiments. Carrageenan (1%) was injected into the footpad for oedema evaluation and into the peritoneal cavity (i.p.), for differential counting of inflammatory cells. Ehrlich ascitic tumour cells (107 viable cells/ml) were injected i.p. and tumour cells were counted after 6 days, by the Trypan blue exclusion method. The differential TIL was counted using smears stained by hematoxylin–eosin. Treatments were made immediately after carrageenan inoculation or once a day, during Ehrlich tumour development, until the animals were killed. Animals were treated with the following preparations: (1) phosphate buffer saline (PBS) solution; (2) dexamethasone (0.5 mg/kg for inflammation model or 4 mg/kg for tumour model) mixed with dexamethasone 7cH or 15cH; (3) dexamethasone (same doses) mixed in PBS. Homeopathic dexamethasone partially blocked the anti-inflammatory effect of pharmacological dexamethasone with regard to paw oedema (two-way ANOVA, P≤0.0008) and polymorphonuclear cell migration (χ2, P=0.0001). No important differences were observed between experimental and control groups, in relation to Ehrlich tumour cells viability or count, or bodyweight, but potentised dexamethasone restored control levels of TIL viability, compared to mice treated with pharmacological doses of dexamethasone (χ2, P≤0.001). The results demonstrate that a potentised substance may change its own pharmacological effects and suggest that ultradilutions effects act mostly on host response.


2022 ◽  
Vol 146 ◽  
pp. 354-364
Author(s):  
Meryem Slighoua ◽  
Ismail Mahdi ◽  
Fatima ez-zahra Amrati ◽  
Nabil Boucetta ◽  
Francesca Di Cristo ◽  
...  

2015 ◽  
Vol 32 (8) ◽  
pp. 1170-1182 ◽  
Author(s):  
A. AlQathama ◽  
J. M. Prieto

Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.


Synapse ◽  
1997 ◽  
Vol 26 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Patrick Emond ◽  
Sylvie Chalon ◽  
Lucette Garreau ◽  
Anne-Marie Dognon ◽  
Sylvie Bodard ◽  
...  
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