Reactions of borohydride in carboxylic acid media: A summary

1989 ◽  
Vol 66 (8) ◽  
pp. 673 ◽  
Author(s):  
Charles F. Nutaitis
Keyword(s):  
Carboxylic Acid ◽  
Acid Media

scholarly journals Spectrophotometric study of the protonation processes of some indole derivatives in sulfuric acid

1999 ◽  
Vol 64 (12) ◽  
pp. 775-787 ◽  
Author(s):  
Blagoja Andonovski ◽  
Goran Stojkovic
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Dissociation Constants ◽  
Uv Spectroscopy ◽  
Spectrophotometric Study ◽  
Protonated Form ◽  
Indole Derivatives ◽  
Acid Media ◽  
Solvent Parameter ◽  
Pka Value

The protonation of 3-methylindole, D-tryptophan, 3-formylindole, 3-acetylindole and indolyl-2-carboxylic acid in sulfuric acid media was studied by UV spectroscopy. The measurement of the absorbance at four selected wavelengths enabled the calculation of the corresponding molar absorptivities. The results were used to calculate the pKa value of the protonated form of the indole derivatives by the Hammett Method. The Hammett postulate (the slope of the plot log [c(BH+)/c(B)]vs. H should be equal to 1) was tested. The dissociation constants and solvent parameter m* were also obtained by applying the Excess Acidity Method. The position of the additional protons in the protonated compounds is discussed.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

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