The Contribution of Ligand Flexibility to Metal Center Geometry Modulated Thermal Cyclization of Conjugated Pyridine and Quinoline Metalloenediynes of Copper(I) and Copper(II)

2001 ◽  
Vol 40 (8) ◽  
pp. 1846-1857 ◽  
Author(s):  
Diwan S. Rawat ◽  
Pedro J. Benites ◽  
Christopher D. Incarvito ◽  
Arnold L. Rheingold ◽  
Jeffrey M. Zaleski
Keyword(s):  
Metal Center ◽  
Thermal Cyclization

Some Problems in the Oxidative Addition and Binding of an Ethylene to a Transition Metal Center.

1987 ◽  
Vol 6 (4) ◽  
pp. 902-902
Author(s):  
Jerome Silestre ◽  
Maria Calhorda ◽  
Roald Hoffman ◽  
Page Stoutland ◽  
Robert Bergman
Keyword(s):  
Transition Metal ◽  
Oxidative Addition ◽  
Metal Center

The First Coordination of an (α-Diazo)phosphine to a Transition-Metal Center

2003 ◽  
Vol 22 (7) ◽  
pp. 1358-1360 ◽  
Author(s):  
Emmanuelle Despagnet-Ayoub ◽  
Heinz Gornitzka ◽  
John Fawcett ◽  
Philip W. Dyer ◽  
Didier Bourissou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Center

scholarly journals Molecular Dynamics of Cobalt Protoporphyrin Antagonism of the Cancer Suppressor REV-ERBβ

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3251
Author(s):  
Taufik Muhammad Fakih ◽  
Fransiska Kurniawan ◽  
Muhammad Yusuf ◽  
Mudasir Mudasir ◽  
Daryono Hadi Tjahjono
Keyword(s):  
Binding Site ◽  
Nuclear Receptor ◽  
Target Genes ◽  
Protoporphyrin Ix ◽  
Binding Energies ◽  
Metal Center ◽  
Complex Nature ◽  
Dynamic Simulations ◽  
Subtle Change ◽  
Cobalt Protoporphyrin

Nuclear receptor REV-ERBβ is an overexpressed oncoprotein that has been used as a target for cancer treatment. The metal-complex nature of its ligand, iron protoporphyrin IX (Heme), enables the REV-ERBβ to be used for multiple therapeutic modalities as a photonuclease, a photosensitizer, or a fluorescence imaging agent. The replacement of iron with cobalt as the metal center of protoporphyrin IX changes the ligand from an agonist to an antagonist of REV-ERBβ. The mechanism behind that phenomenon is still unclear, despite the availability of crystal structures of REV-ERBβ in complex with Heme and cobalt protoporphyrin IX (CoPP). This study used molecular dynamic simulations to compare the effects of REV-ERBβ binding to Heme and CoPP, respectively. The initial poses of Heme and CoPP in complex with agonist and antagonist forms of REV-ERBβ were predicted using molecular docking. The binding energies of each ligand were calculated using the MM/PBSA method. The computed binding affinity of Heme to REV-ERBβ was stronger than that of CoPP, in agreement with experimental results. CoPP altered the conformation of the ligand-binding site of REV-ERBβ, disrupting the binding site for nuclear receptor corepressor, which is required for REV-ERBβ to regulate the transcription of downstream target genes. Those results suggest that a subtle change in the metal center of porphyrin can change the behavior of porphyrin in cancer cell signaling. Therefore, modification of porphyrin-based agents for cancer therapy should be conducted carefully to avoid triggering unfavorable effects.

Bimetallic Group 6 Tricarbonyls Triply-Bridged by Bis(phenylthio)alkane Bidentate Ligands

2010 ◽  
Vol 93-94 ◽  
pp. 13-16
Author(s):  
Khalil J. Asali
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Thermodynamic Stability ◽  
Chlorinated Hydrocarbons ◽  
Metal Center ◽  
Molar Ratio ◽  
Bidentate Ligands ◽  
Group 6 ◽  
Ft Ir

Reactions of the labile complex (Me3tach)M(CO)3 (Me3tach = 1,3,5-trimethyl-1,3,5-triazacyclohexane; M = W, Mo) with bis(phenylthio)alkanes ( = PhS(CH2)nSPh), (2:3 molar ratio) in CH2Cl2 as solvent (at 35 oC M = W, 0 oC M = Mo) afforded in good yields bimetallic tricarbonyl complexes triply- bridged by bis(phenylthio)alkanes of the type [M(CO)3]2(μ-PhS-(CH2)n-SPh)3 [n = 3 (a), 4 (b), 5 (c), 6 (d); M = W (1), Mo (2)]. These new triply-bridged complexes were characterized by 1H NMR, FT-IR and elemental analysis. Additionally, it has been observed that the thermodynamic stability of some of these new complexes in chlorinated hydrocarbons depends mainly on the nature of the metal center and varies in the order W >> Mo.

scholarly journals Biological effects of anionic meso-tetrakis (para-sulfonatophenyl) porphyrins modulated by the metal center. Studies in rat liver mitochondria

2009 ◽  
Vol 181 (3) ◽  
pp. 400-408 ◽  
Author(s):  
Felipe Samuel Pessoto ◽  
Natalia Mayumi Inada ◽  
Maria de Fátima Nepomuceno ◽  
Ana Célia Ruggiero ◽  
Otaciro R. Nascimento ◽  
...  
Keyword(s):  
Rat Liver ◽  
Biological Effects ◽  
Liver Mitochondria ◽  
Metal Center ◽  
Rat Liver Mitochondria

Influence of the metal center on the morphology of coordination compounds thin films

1999 ◽  
Vol 101 (1-3) ◽  
pp. 140-141 ◽  
Author(s):  
F. Toffolo ◽  
M. Brinkmann ◽  
O. Greco ◽  
F. Biscarini ◽  
C. Taliani ◽  
...  
Keyword(s):  
Thin Films ◽  
Coordination Compounds ◽  
Metal Center

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

Polyhedron ◽  
2021 ◽  
Vol 209 ◽  
pp. 115453
Author(s):  
Fatali E. Huseynov ◽  
Ghodrat Mahmoudi ◽  
Sevinc R. Hajiyeva ◽  
Nazim T. Shamilov ◽  
Fedor I. Zubkov ◽  
...  
Keyword(s):  
Metal Center ◽  
Coordination Environment
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