Equilibrium studies of copper(II) complexes of iminodiacetates with amino acid esters and the kinetics of ester hydrolysis

1969 ◽  
Vol 8 (4) ◽  
pp. 907-913 ◽  
Author(s):  
Bruce E. Leach ◽  
Robert J. Angelici
Keyword(s):  
Amino Acid ◽  
Ester Hydrolysis ◽  
Amino Acid Esters ◽  
Equilibrium Studies ◽  
Kinetics Of ◽  
Acid Esters

Destruction of Leishmania mexicana amazonensis amastigotes by leucine methyl ester: protection by other amino acid esters

Parasitology ◽  
1987 ◽  
Vol 95 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Silvia C. Alfieri ◽  
V. Zilberfarb ◽  
M. Rabinovitch
Keyword(s):  
Amino Acid ◽  
Methyl Ester ◽  
Protective Effect ◽  
Ester Hydrolysis ◽  
Amino Acid Esters ◽  
Protective Activity ◽  
Leishmania Mexicana ◽  
Effective Prevention ◽  
Infected Cells ◽  
Acid Esters

SUMMARYl-Amino acid esters, such as leucine methyl ester (Leu-OMe) can destroy intracellular as well as isolated amastigotes of Leishmania mexicana amazonensis by a mechanism which may involve ester hydrolysis by parasite enzymes. We show here that several other esters prevented the killing of the amastigotes by Leu-OMe. Destruction of Leishmania within macrophages in culture was assessed microscopically and viability of isolated parasites was monitored by reduction of the tetrazolium MTT. The main features of the protective effect were similar for intracellular and for isolated amastigotes. Thus, (i) effective prevention of parasite killing required that the protective ester be present in the medium prior to and during exposure of infected cells or parasites to Leu-OMe; (ii) the same esters protected intracellular and isolated Leishmania against damage by Leu-OMe. Ranks of protective activity, as determined on isolated amastigotes were: Gly-OBz > Tyr-OMe > Ile-OMe > Met-OMe > Val-OMe > Ala-OMe > Gly-OMe > D-Leu-OMe; (iii) several esters were inactive in both systems (Leu-OBz, Trp-OMe and Phe-OMe). Protective activity was associated with leishmanicidal (e.g. Gly-OBz, Tyr-OMe) as well as with non-leishmanicidal (e.g. Ile-OMe, Val-OMe) esters. The results are compatible with the hypothesis that protective esters inhibit the activity of parasite enzyme(s) which hydrolyse Leu-OMe.

Structure dependence in the solvolysis kinetics of amino acid esters

2010 ◽  
Vol 51 (25) ◽  
pp. 3280-3283 ◽  
Author(s):  
John Haseltine ◽  
Jason W. Runyon
Keyword(s):  
Amino Acid ◽  
Amino Acid Esters ◽  
Structure Dependence ◽  
Kinetics Of ◽  
Acid Esters

scholarly journals Enantioselective ester hydrolysis by an achiral catalyst co-embedded with chiral amphiphiles into a vesicle membrane

RSC Advances ◽  
2016 ◽  
Vol 6 (50) ◽  
pp. 44456-44458 ◽  
Author(s):  
M. Poznik ◽  
B. König
Keyword(s):  
Amino Acid ◽  
Ester Hydrolysis ◽  
Phospholipid Vesicle ◽  
Amino Acid Esters ◽  
Vesicle Membrane ◽  
Acid Esters

Co-embedding of an amphiphilic non-chiral hydrolysis catalyst with amphiphilic chiral additives into the membrane of a phospholipid vesicle induces different rates of ester hydrolysis for enantiomeric amino acid esters.

Kinetics of base hydrolysis of α-amino acid esters catalyzed by [Pd(Et4en)(H2O)2]2+

2010 ◽  
Vol 63 (14-16) ◽  
pp. 2498-2506 ◽  
Author(s):  
Mohamed M. Shoukry ◽  
Abdul Aziz Al-Najjar ◽  
Wafaa M. Hosny ◽  
Afkar K. Abdel Hadi ◽  
Afaf A. Mahgoub ◽  
...  
Keyword(s):  
Amino Acid ◽  
Base Hydrolysis ◽  
Amino Acid Esters ◽  
Kinetics Of ◽  
Hydrolysis Of ◽  
Acid Esters
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