Functionalization of chlorins towards potential photosensitizers for photodynamic therapy

Photophysical properties of chlorins predestine this type of hydroporphyrins for photodynamic therapy and other diagnostic/therapeutic applications. Artificial chlorins 3a and 4a derived from the red blood pigment heme form a platform for functionalizations with respect towards potentially biologically active photosensitizers and fluorescense markers. Chlorin estrogen derivatives 8a, 8b might be useful as sensitizers which bind selectively to (tumor) cell tissue containing estrogen receptors, [Formula: see text] breast cancer cells.

Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A

The first synthesis of the (Z)-indolic enamide-containing antibacterial marine natural product halocyamine A is reported.

Synthesis of novel porphyrin and chlorin phosphonic acids and their immobilization on metal oxides

In this study an easy and flexible access to porphyrin and chlorin phosphonic acids is presented. Novel types of phosphonic acid terminated porphyrins and chlorins were synthesized starting from commercially available red blood pigment hemin chloride. Phosphonic acid groups were linked to the porphyrinoids by amide coupling via appropriate spacer moieties. Self-assembled monolayers of the synthesized phosphonates on mesoporous TiO2 electrodes of approximately 3 μm thickness were formed. Surface concentrations in a range of 1 to 4 × 10-8 mol.cm-2 could be determined by UV-vis spectroscopy.

Synthesis and self-assembly of a novel cobalt(II) porphyrin lipoic acid derivative on gold

A novel Co(II) porphyrin lipoic acid derivative was synthesized starting from the commerically available red blood pigment hemin. The disulfide functionalities of the lipoic acid moieties allowed its immobilization on gold by a self-assembly method. The Co(II) porphyrin self-assembled monolayer (SAMs) on gold (111) surfaces were characterized electrochemically through monolayer reductive desorption and evaluation of the redox properties of the immobilized molecules in organic medium, and by scanning tunneling microscopy (STM). It was found that after assembly the Co(II) porphyrin is electroactive exhibiting the typical redox processes observed for its precursor without the appended lipoic acid in solution. A coverage of 2.7 × 10-10 mol.cm -2 has been estimated assuming that four electrons (one per each sulfur atom) are involved in the process. The porphyrin-modified gold electrodes exhibit catalytic acitivity demonstrated towards the reduction of molecular oxygen in acidic solution.