The ionic hydrogen bond. 4. Intramolecular and multiple bonds. Protonation and complexes of amides and amino acid derivatives

1984 ◽  
Vol 106 (2) ◽  
pp. 278-283 ◽  
Author(s):  
Michael Meot-Ner
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Multiple Bonds

ChemInform Abstract: Hydrogen Bond Controlled anti-Aza-Michael Addition: Diastereoselective Synthesis of Cyclobutene-Containing Amino Acid Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
David Tejedor ◽  
Gabriela Mendez-Abt ◽  
Javier Gonzalez-Platas ◽  
Israel Fernandez ◽  
Fernando Garcia-Tellado
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Michael Addition ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis

scholarly journals Hydrogen Bond Controlled Anti-Aza-Michael Addition: Diastereoselective Synthesis of Cyclobutene-Containing Amino Acid Derivatives

2015 ◽  
Vol 2015 (16) ◽  
pp. 3462-3469 ◽  
Author(s):  
David Tejedor ◽  
Gabriela Méndez-Abt ◽  
Javier González-Platas ◽  
Israel Fernández ◽  
Fernando García-Tellado
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Michael Addition ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis

Four oxoindole-linked α-alkoxy-β-amino acid derivatives

2015 ◽  
Vol 71 (4) ◽  
pp. 322-329 ◽  
Author(s):  
Krishnan Ravikumar ◽  
Balasubramanian Sridhar ◽  
Jagadeesh Babu Nanubolu ◽  
Tamilselvan Rajasekaran ◽  
Basi Venkata Subba Reddy
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Hydrogen Bonds ◽  
Benzyl Alcohol ◽  
Chemical Reaction ◽  
Amide Group ◽  
Amino Acid Derivatives ◽  
Relative Configuration ◽  
Extended Conformation ◽  
Hydrogen Bond Interactions

Four structures of oxoindolyl α-hydroxy-β-amino acid derivatives, namely, methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-methoxy-2-phenylacetate, C24H28N2O6, (I), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-ethoxy-2-phenylacetate, C25H30N2O6, (II), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-[(4-methoxybenzyl)oxy]-2-phenylacetate, C31H34N2O7, (III), and methyl 2-[(anthracen-9-yl)methoxy]-2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-phenylacetate, C38H36N2O6, (IV), have been determined. The diastereoselectivity of the chemical reaction involving α-diazoesters and isatin imines in the presence of benzyl alcohol is confirmed through the relative configuration of the two stereogenic centres. In esters (I) and (III), the amide group adopts ananticonformation, whereas the conformation issynin esters (II) and (IV). Nevertheless, the amide group forms intramolecular N—H...O hydrogen bonds with the ester and ether O atoms in all four structures. The ether-linked substituents are in the extended conformation in all four structures. Ester (II) is dominated by intermolecular N—H...O hydrogen-bond interactions. In contrast, the remaining three structures are sustained by C—H...O hydrogen-bond interactions.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals Synthesis and antimicrobial activity of some novel 1,2-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines bearing amino acid moiety

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2905-2916
Author(s):  
Mounir A. A. Mohamed ◽  
Adnan A. Bekhit ◽  
Omyma A. Abd Allah ◽  
Asmaa M. Kadry ◽  
Tamer M. Ibrahim ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Green Chemistry ◽  
Antimicrobial Activities ◽  
Amino Acid Derivatives ◽  
Acid Moiety ◽  
Amino Acid Moiety

A new series of [1,2,4]-triazole bearing amino acid derivatives were synthesized under green chemistry conditions and evaluated for their antimicrobial activities.

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