EVIDENCE FOR THE EXCRETION OF FORMIMINO-GLUTAMIC ACID FOLLOWING FOLIC ACID ANTAGONIST THERAPY IN ACUTE LEUKEMIA

1956 ◽  
Vol 78 (23) ◽  
pp. 6205-6206 ◽  
Author(s):  
Harry P. Broquist
Keyword(s):  
Folic Acid ◽  
Acute Leukemia ◽  
Glutamic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 ◽  
Vol 238 (23) ◽  
pp. 787-793 ◽  
Author(s):  
Sidney Farber ◽  
Louis K. Diamond ◽  
Robert D. Mercer ◽  
Robert F. Sylvester ◽  
James A. Wolff
Keyword(s):  
Folic Acid ◽  
Acute Leukemia ◽  
Glutamic Acid ◽  
Folic Acid Antagonist ◽  
Acid Antagonist ◽  
Leukemia In Children

Effects of Folic Acid Antagonist Therapy on Urinary Excretion of Formic Acid by Humans.

1958 ◽  
Vol 98 (1) ◽  
pp. 144-147 ◽  
Author(s):  
H. H. Hiatt ◽  
J. C. Rabinowitz ◽  
R. Toch ◽  
M. Goldstein
Keyword(s):  
Folic Acid ◽  
Urinary Excretion ◽  
Formic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Scurvy Following Folic Acid Antagonist Therapy

Radiology ◽  
1956 ◽  
Vol 67 (3) ◽  
pp. 412-415 ◽  
Author(s):  
John M. Dennis ◽  
Raul Mercado
Keyword(s):  
Folic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The Use of Methotrexate in Rheumatoid Arthritis

1985 ◽  
Vol 19 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Peter W. Letendre ◽  
Douglas J. DeJong ◽  
Donald R. Miller
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Folic Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Systemic Administration ◽  
Refractory Disease ◽  
Controlled Clinical Trials ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5–15 mg/wk in a “pulse” fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.

Sign in / Sign up

Export Citation Format

Share Document