scholarly journals The future of folic acid antagonist therapy in rheumatoid arthritis

2009 ◽  
Vol 60 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Christoph Fiehn
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist ◽  
The Future

The Use of Methotrexate in Rheumatoid Arthritis

1985 ◽  
Vol 19 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Peter W. Letendre ◽  
Douglas J. DeJong ◽  
Donald R. Miller
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Folic Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Systemic Administration ◽  
Refractory Disease ◽  
Controlled Clinical Trials ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5–15 mg/wk in a “pulse” fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.

Effects of Folic Acid Antagonist Therapy on Urinary Excretion of Formic Acid by Humans.

1958 ◽  
Vol 98 (1) ◽  
pp. 144-147 ◽  
Author(s):  
H. H. Hiatt ◽  
J. C. Rabinowitz ◽  
R. Toch ◽  
M. Goldstein
Keyword(s):  
Folic Acid ◽  
Urinary Excretion ◽  
Formic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Scurvy Following Folic Acid Antagonist Therapy

Radiology ◽  
1956 ◽  
Vol 67 (3) ◽  
pp. 412-415 ◽  
Author(s):  
John M. Dennis ◽  
Raul Mercado
Keyword(s):  
Folic Acid ◽  
Antagonist Therapy ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Folic acid antagonist use before and during pregnancy and risk for selected birth defects

2020 ◽  
Vol 112 (18) ◽  
pp. 1526-1540
Author(s):  
Stephen M. Kerr ◽  
Samantha E. Parker ◽  
Allen A. Mitchell ◽  
Sarah C. Tinker ◽  
Martha M. Werler
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

Precipitation of Menstrual Bleeding in Monkeys by a Folic Acid Antagonist

Science ◽  
1950 ◽  
Vol 112 (2901) ◽  
pp. 147-147 ◽  
Author(s):  
M. X. Zarrow ◽  
F. L. Hisaw ◽  
H. A. Salhanick
Keyword(s):  
Folic Acid ◽  
Menstrual Bleeding ◽  
Folic Acid Antagonist ◽  
Acid Antagonist
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