Studies on Carcinogenic Amines. I. L- and D-Amino Acid Derivatives of 2-Aminofluorene, 4-Aminobiphenyl and 4,4'-Diaminobiphenyl, and their Susceptibility to Hydrolysis by Tissue Homogenates

A new series of amino acid derivatives of quinolines was synthesized through the hydrolysis of amino acid methyl esters of quinoline carboxamides with alkali hydroxide. The compounds were purified on silica gel by column chromatography and further characterized by TLC, NMR and ESI-TOF mass spectrometry. All compounds were screened for in vitro antimicrobial activity against different bacterial strains using the microdilution method. Most of the synthesized amino acid-quinolines show more potent or equipotent inhibitory action against the tested bacteria than their correspond esters. In addition, many of them exhibit fluorescent properties and could possibly be utilized as fluorophores. Molecular docking and simulation studies of the compounds at putative bacterial target enzymes suggest that the antimicrobial potency of these synthesized analogues could be due to enzyme inhibition via their favorable binding at the fluoroquinolone binding site at the GyrA subunit of DNA gyrase and/or the ParC subunit of topoisomerase-IV.

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Synthesis of Some Amino Acid Derivatives of Styrene1

Journal of the American Chemical Society ◽

10.1021/ja01511a026 ◽

1959 ◽

Vol 81 (2) ◽

pp. 377-382 ◽

Cited By ~ 44

Author(s):

L. R. Morris ◽

R. A. Mock ◽

C. A. Marshall ◽

J. H. Howe

Keyword(s):

Amino Acid ◽

Amino Acid Derivatives ◽

Derivatives Of

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Synthesis of amino acid derivatives of indole-3-acetic acid

Journal of Chemical Research ◽

10.3184/030823405774663129 ◽

2005 ◽

Vol 2005 (10) ◽

pp. 640-642 ◽

Cited By ~ 1

Author(s):

Ying Liu ◽

Liang Zhao ◽

Liang Liu ◽

Lin-Yi Wei ◽

Lu-Hua Lai

Keyword(s):

Acetic Acid ◽

Amino Acid ◽

Amino Acid Derivatives ◽

H Nmr ◽

Derivatives Of ◽

Indole 3 Acetic Acid

Amino acid derivatives of a modified indole-3-acetic acid have been synthesised. Fourteen new dipeptide-like compounds 3–4 were obtained and their structures were elucidated based on the IR, 1H NMR, MS spectra.

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New Compounds: Amino Acid Derivatives of Nicotinic Acid

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600610338 ◽

1972 ◽

Vol 61 (3) ◽

pp. 477-478 ◽

Cited By ~ 3

Author(s):

M.T. Wu ◽

R.E. Lyle

Keyword(s):

Amino Acid ◽

Nicotinic Acid ◽

Amino Acid Derivatives ◽

New Compounds ◽

Derivatives Of

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Synthesis of amino acid derivatives of benzofuroxan

Doklady Chemistry ◽

10.1134/s0012500813060013 ◽

2013 ◽

Vol 450 (2) ◽

pp. 149-151 ◽

Cited By ~ 5

Author(s):

I. V. Serkov ◽

E. A. Chugunova ◽

A. R. Burilov ◽

S. O. Bachurin

Keyword(s):

Amino Acid ◽

Amino Acid Derivatives ◽

Derivatives Of

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ChemInform Abstract: Prodrugs of Neuron-Selective Monoamine Oxidase Inhibitors: Amino Acid Derivatives of 1-(4-Aminophenyl)-2-aminopropanes.

ChemInform ◽

10.1002/chin.199929187 ◽

2010 ◽

Vol 30 (29) ◽

pp. no-no

Author(s):

Lennart Florvall ◽

Ingrid Fagervall ◽

Lars-Gunnar Larsson ◽

Svante B. Ross

Keyword(s):

Amino Acid ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitors ◽

Amino Acid Derivatives ◽

Derivatives Of

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Synthesis of New 6,7(N,O)-Heterocyclic 1,4-Naphthoquinones

Biointerface Research in Applied Chemistry ◽

10.33263/briac116.1390313910 ◽

2021 ◽

Vol 11 (6) ◽

pp. 13903-13910

Keyword(s):

Amino Acid ◽

High Activity ◽

Biologically Active ◽

Amino Acid Derivatives ◽

Antimicrobial Substances ◽

Derivatives Of

As a result of the carried out research it was synthesized an order of new potentially biologically active modified N-,O-contained heterocycles on the base of amino acid derivatives of 2,6,7-nitrogen substituted-3-chloro-1,4-naphthoquinone. It was established that among synthesized compounds, there are potential antimicrobial substances with high activity.

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